Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4928797..4930382 Replicon chromosome
Accession NZ_CP024842
Organism Pectobacterium versatile strain 3-2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OA04_RS22510 Protein ID WP_107333666.1
Coordinates 4928797..4930116 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OA04_RS22515 Protein ID WP_010302402.1
Coordinates 4930116..4930382 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OA04_RS22485 4924770..4924910 + 141 WP_005976668.1 50S ribosomal protein L34 -
OA04_RS22490 4924929..4925288 + 360 WP_010302382.1 ribonuclease P protein component -
OA04_RS22495 4925252..4925509 + 258 WP_010302384.1 membrane protein insertion efficiency factor YidD -
OA04_RS22500 4925512..4927146 + 1635 WP_039485128.1 membrane protein insertase YidC -
OA04_RS22505 4927276..4928640 + 1365 WP_107333665.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
OA04_RS22510 4928797..4930116 - 1320 WP_107333666.1 type II toxin-antitoxin system HipA family toxin Toxin
OA04_RS22515 4930116..4930382 - 267 WP_010302402.1 helix-turn-helix domain-containing protein Antitoxin
OA04_RS22520 4930543..4931109 + 567 WP_103862406.1 hypothetical protein -
OA04_RS22525 4931260..4932165 + 906 WP_103862407.1 HNH endonuclease -
OA04_RS22530 4932229..4933080 - 852 WP_107333667.1 SDR family oxidoreductase -
OA04_RS22535 4933223..4933633 + 411 WP_103862408.1 helix-turn-helix transcriptional regulator -
OA04_RS22540 4933683..4934234 - 552 WP_107333668.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49253.37 Da        Isoelectric Point: 6.5030

>T88813 WP_107333666.1 NZ_CP024842:c4930116-4928797 [Pectobacterium versatile]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQSYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLDKVGKDSVGALQIVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPFSTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILAEFAQTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T88813 NZ_CP024842:c4930116-4928797 [Pectobacterium versatile]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGGGTGGGGATTCTGACCAAAACGGGCAGTGGAGCACATCATTTTTC
CTATGATGCGAACTGGCTCGGGTTGCCGGGGAGTCGCCCCATTTCGCTTTCTATGCCGCTACGTCATCAGTCCTATCAAG
GTGATGAGGTTTATAACTTCTTCGACAATTTGTTGCCAGATAACCCGGATATCAGAAGACGGATTGTCGCCAGGCATCAC
GCGGATTCCACCCAACCGTTTGATCTGCTGGATAAAGTGGGGAAAGACAGTGTCGGGGCGTTGCAAATAGTGCCGCAGGG
TACACCTGTGCACGATATAAAAAAGATCGAATACAAAACCTTATCCGAGCAGCAGCTTGAAAACATACTGACCGGATATC
TGTCCGATGCCCCGCTGGGTATGATTGATACTGAAGACGATTTTCGTATCTCTATCGCGGGCGCACAGGAAAAGACGGCG
CTGCTTTATCTGGATGATCACTGGTGCCTGCCCTTCAGTACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGCCTGCTCATTGCCAAGGCAT
TTGGGCTGCCAGTGCCGCACTGTTTTATGATCAACGCTGGCAAGATAAAGGCGTTGGCGGTGGAGCGTTTTGATCGTAAA
TACGCCTCGGATGTCAGTTGGATTATGCGGCTACCACAAGAGGATTTTTGTCAGGTATTAAACGTTCCTTCCGCACTGAA
ATATGAAAATCATGGTGGACCGGGTATTTCCGCCATTATGTCGTTTCTATTGGGGTCGGTTGATCCAGAAAGAGATCGTT
ATCGCTTTATGCAGGCTCAGGTACTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAACTTTTCCCTGTTTATT
GAATCTGAGGGGCGATATCGACTCACACCTTTCTATGACATTCTCTCTATGTATCCGGCGATGGGCGGACGGGGAATTGA
CCGCAGAGAGGCCAAACTGGCGATGGGATTAACTGGCTCAAGAGGCAAGAAATATGCGATTGAGCAGATCTTTCCCCGGC
ATTTTTTCCAGACGGCGAAGGCCGTTGGGTTTGCCAGAGAATCAATGGAAAACATTCTGGCGGAGTTTGCACAAACCGTT
GAGACCGTTATGACGACTGTTGGAAGCCAACTGCCTGTGGATTTTCCTACTCATATCAGTGAGGCAATTCTGGCCGGATT
GCAGGCCAGATCGAGACGGCTCATGAGCGGATGGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9887.16 Da        Isoelectric Point: 9.7281

>AT88813 WP_010302402.1 NZ_CP024842:c4930382-4930116 [Pectobacterium versatile]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTANNEASV
ASSWKEEW

Download         Length: 267 bp

>AT88813 NZ_CP024842:c4930382-4930116 [Pectobacterium versatile]
ATGAAGGTCACCAACAGCAAGCAGCTTAGCAGCTACCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGCTTCGAGCAACATCCTGATTCCACCAAGCTGGAAACCTTCT
TTAAAATCCTGTCGGCATTGAACTTAGAACTTACTGTTACGCCCCGAAATGTGGATACCGCCAATAACGAAGCCTCTGTT
GCATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References