Detailed information of TA system TA088812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4758797..4759431
• Replicon: chromosome
• Accession: NZ_CP024842
• Organism: Pectobacterium versatile strain 3-2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: OA04_RS21735
• Protein ID: WP_103862315.1
• Coordinates: 4759156..4759431 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A221T3Z5
• Locus tag: OA04_RS21730
• Protein ID: WP_010308714.1
• Coordinates: 4758797..4759159 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OA04_RS21725	4754793..4758536	-	3744	WP_107333598.1	DUF4132 domain-containing protein	-
OA04_RS21730	4758797..4759159	-	363	WP_010308714.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
OA04_RS21735	4759156..4759431	-	276	WP_103862315.1	type II toxin-antitoxin system HicA family toxin	Toxin
OA04_RS21740	4759661..4760185	-	525	WP_103862316.1	cell-envelope stress modulator CpxP	-
OA04_RS21745	4760339..4761037	+	699	WP_010308725.1	envelope stress response regulator transcription factor CpxR	-
OA04_RS21750	4761034..4762404	+	1371	WP_107333599.1	envelope stress sensor histidine kinase CpxA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-85)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10006.60 Da
• Isoelectric Point: 11.1875

>T88812 WP_103862315.1 NZ_CP024842:c4759431-4759156 [Pectobacterium versatile]
MQGKIASLRKKQRETLSHIFKTPVLSGVKWSSIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T88812 NZ_CP024842:c4759431-4759156 [Pectobacterium versatile]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACACTGAGCCACATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAGTATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGGTCACGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGGTTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGTGCCCTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13495.29 Da
• Isoelectric Point: 4.6225

>AT88812 WP_010308714.1 NZ_CP024842:c4759159-4758797 [Pectobacterium versatile]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERHISVNTFIVETLSEHLKQA

Nucleotide

• Length: 363 bp

>AT88812 NZ_CP024842:c4759159-4758797 [Pectobacterium versatile]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCTGCCATTATCAGTTACGTACCGGAAATTGG
TATGTTTCGTGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTACCCTGAATCATTCGGGGAACGACTGACCATTGCGGCCGCTGAACGTCACATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A221T3Z5