Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4710124..4710741 Replicon chromosome
Accession NZ_CP024842
Organism Pectobacterium versatile strain 3-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OA04_RS21530 Protein ID WP_103862292.1
Coordinates 4710124..4710303 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OA04_RS21535 Protein ID WP_103862293.1
Coordinates 4710331..4710741 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OA04_RS21505 4705359..4706519 - 1161 WP_107333584.1 cystathionine gamma-synthase -
OA04_RS21510 4706707..4707024 + 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
OA04_RS21515 4707248..4708045 + 798 WP_103943591.1 ABC transporter ATP-binding protein -
OA04_RS21520 4708055..4709017 + 963 WP_107333585.1 ABC transporter substrate-binding protein -
OA04_RS21525 4709014..4710024 + 1011 WP_107333586.1 iron ABC transporter permease -
OA04_RS21530 4710124..4710303 + 180 WP_103862292.1 type II toxin-antitoxin system HicA family toxin Toxin
OA04_RS21535 4710331..4710741 + 411 WP_103862293.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OA04_RS21540 4710824..4711039 - 216 WP_010281510.1 50S ribosomal protein L31 -
OA04_RS21545 4711311..4713509 + 2199 WP_103943585.1 primosomal protein N' -
OA04_RS21550 4713804..4714847 + 1044 WP_103862295.1 DNA-binding transcriptional regulator CytR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6546.67 Da        Isoelectric Point: 10.7838

>T88811 WP_103862292.1 NZ_CP024842:4710124-4710303 [Pectobacterium versatile]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGV

Download         Length: 180 bp

>T88811 NZ_CP024842:4710124-4710303 [Pectobacterium versatile]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGGTTAGTCACAATCCCCCACCCGAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGAGTATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14461.35 Da        Isoelectric Point: 4.4227

>AT88811 WP_103862293.1 NZ_CP024842:4710331-4710741 [Pectobacterium versatile]
MFYPIAIEAGDETHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIGLLVEMGQDIPTVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT88811 NZ_CP024842:4710331-4710741 [Pectobacterium versatile]
ATGTTTTATCCTATTGCAATTGAAGCAGGCGACGAGACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGTTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGGACTGTTGGTCGAAA
TGGGCCAGGATATTCCCACCGTGTCGTCAGTAGGCCAACTAGCAAAAAACGCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATTGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAACGTCACGCTGCCTAAGTCGCTGATTGACCGCAT
TGATCGTTGCGTGGCGAGTAACCCAGAATTTAAAAGTCGTTCGGGTTTTCTCGCACAGGCGGCATTAGAACGAATCTCGT
CTTCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References