Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4220745..4221295 Replicon chromosome
Accession NZ_CP024842
Organism Pectobacterium versatile strain 3-2

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3R8NCD5
Locus tag OA04_RS19275 Protein ID WP_039483443.1
Coordinates 4220987..4221295 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3R8NHE1
Locus tag OA04_RS19270 Protein ID WP_052012050.1
Coordinates 4220745..4220984 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OA04_RS19250 4216186..4216497 - 312 WP_107333463.1 AzlD domain-containing protein -
OA04_RS19255 4216494..4217228 - 735 WP_107333464.1 AzlC family ABC transporter permease -
OA04_RS19260 4217368..4218204 - 837 WP_102117374.1 AraC family transcriptional regulator -
OA04_RS19265 4218419..4220038 - 1620 WP_107333465.1 Tar ligand binding domain-containing protein -
OA04_RS19270 4220745..4220984 + 240 WP_052012050.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OA04_RS19275 4220987..4221295 + 309 WP_039483443.1 CcdB family protein Toxin
OA04_RS19280 4221440..4221604 - 165 WP_102117376.1 glucose uptake inhibitor SgrT -
OA04_RS19285 4221695..4223353 + 1659 WP_102117377.1 HTH-type transcriptional regulator SgrR -
OA04_RS19290 4223568..4224551 + 984 WP_145962346.1 thiamine ABC transporter substrate binding subunit -
OA04_RS19295 4224527..4226134 + 1608 WP_107333467.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11785.63 Da        Isoelectric Point: 9.3363

>T88810 WP_039483443.1 NZ_CP024842:4220987-4221295 [Pectobacterium versatile]
MQYKVYRNNGNSNSYPYLLNIQSDIIGELHTRLVIPLFPLHKIARPPARRLTPIVTVEGNDYLIMTHEMASVRRSQLGHE
VMDAQVYRKTIKDAVDFLLDGF

Download         Length: 309 bp

>T88810 NZ_CP024842:4220987-4221295 [Pectobacterium versatile]
ATGCAATATAAAGTTTACCGTAATAACGGTAACAGCAACTCATACCCTTACCTGCTCAACATCCAAAGTGACATCATCGG
GGAATTACATACCCGCCTGGTGATACCGTTGTTTCCACTACACAAAATTGCCAGACCACCAGCTCGAAGGCTAACGCCGA
TAGTCACTGTCGAAGGCAACGATTACCTGATAATGACCCATGAAATGGCGAGCGTACGCCGCTCACAACTTGGCCATGAA
GTTATGGATGCGCAGGTGTACCGAAAAACAATCAAGGACGCCGTTGATTTCCTGCTTGATGGGTTCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9022.34 Da        Isoelectric Point: 10.0137

>AT88810 WP_052012050.1 NZ_CP024842:4220745-4220984 [Pectobacterium versatile]
MPVTSVRHKKTVSVTLEPVLLQQAREAGINLSAILTEALKREIRLSEGEKWKQQNQKALQELNRITDKHGLLSDDDRTF

Download         Length: 240 bp

>AT88810 NZ_CP024842:4220745-4220984 [Pectobacterium versatile]
ATGCCCGTAACAAGCGTTCGTCATAAAAAAACGGTCAGTGTGACGCTGGAACCCGTGTTGCTCCAACAGGCACGTGAAGC
CGGAATTAACTTATCCGCAATACTCACCGAGGCGCTGAAGAGAGAAATTCGCCTTTCTGAAGGGGAAAAATGGAAGCAGC
AGAACCAGAAGGCATTACAGGAACTAAACCGTATCACAGATAAACACGGCTTATTATCCGACGATGACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8NCD5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8NHE1

References