Detailed information of TA system TA088807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 3487800..3488384
• Replicon: chromosome
• Accession: NZ_CP024842
• Organism: Pectobacterium versatile strain 3-2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: OA04_RS15870
• Protein ID: WP_102119239.1
• Coordinates: 3488052..3488384 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A7T5U8Q8
• Locus tag: OA04_RS15865
• Protein ID: WP_038925224.1
• Coordinates: 3487800..3488051 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OA04_RS15840	3483346..3484149	-	804	WP_103940867.1	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	-
OA04_RS15845	3484146..3484940	-	795	WP_107333211.1	hydroxyethylthiazole kinase	-
OA04_RS15850	3485172..3486401	+	1230	WP_159051015.1	tyrosine-type recombinase/integrase	-
OA04_RS15855	3486417..3486701	+	285	Protein_3046	integrase	-
OA04_RS15860	3486975..3487229	+	255	WP_107333213.1	hypothetical protein	-
OA04_RS15865	3487800..3488051	+	252	WP_038925224.1	PbsX family transcriptional regulator	Antitoxin
OA04_RS15870	3488052..3488384	+	333	WP_102119239.1	endoribonuclease MazF	Toxin
OA04_RS15875	3488456..3489124	+	669	WP_107333214.1	HAD hydrolase-like protein	-
OA04_RS15880	3489473..3489658	+	186	WP_107333215.1	hypothetical protein	-
OA04_RS15885	3489729..3490196	-	468	WP_107333216.1	pyocin immunity protein	-
OA04_RS15890	3490193..3491984	-	1792	Protein_3053	S-type pyocin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3485172..3503122	17950

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-109)

Antitoxin

• Antitoxin PemI-like (3-82)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12191.03 Da
• Isoelectric Point: 7.0819

>T88807 WP_102119239.1 NZ_CP024842:3488052-3488384 [Pectobacterium versatile]
MVSRFVPDSGDLIWLDFDPVVGHEQGGHRPAVVLSPFPYNNLTGMCLCVPCTTQRKGYNFEVELSGDRESVALADQVTCV
DWRNRKATKKGKVTIDELELIRAKAKALIG

Nucleotide

• Length: 333 bp

>T88807 NZ_CP024842:3488052-3488384 [Pectobacterium versatile]
ATGGTTTCTCGTTTTGTTCCTGATTCCGGCGATTTGATCTGGTTAGATTTTGATCCAGTAGTGGGGCATGAACAGGGAGG
ACATCGCCCCGCTGTTGTTCTTAGCCCTTTTCCTTATAATAATTTGACCGGAATGTGCTTATGCGTCCCCTGCACAACAC
AACGTAAAGGATATAACTTTGAAGTCGAATTATCTGGAGACCGTGAAAGCGTGGCTCTCGCCGATCAGGTTACTTGTGTA
GACTGGCGTAACCGTAAGGCAACAAAGAAAGGTAAAGTAACAATCGACGAGTTAGAACTCATCAGAGCAAAAGCGAAGGC
TTTGATTGGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9466.97 Da
• Isoelectric Point: 4.8047

>AT88807 WP_038925224.1 NZ_CP024842:3487800-3488051 [Pectobacterium versatile]
MIDVPVKKWGNSPAIRLSSSVMQAFDMTFNDSFDMEIRETEIALIPKKKPKYQFTLDELLEGMTPEHVHEKVDFGAPVGK
ELL

Nucleotide

• Length: 252 bp

>AT88807 NZ_CP024842:3487800-3488051 [Pectobacterium versatile]
ATGATCGATGTCCCGGTTAAAAAATGGGGAAACTCACCTGCAATACGGCTTTCCTCATCTGTTATGCAAGCGTTTGATAT
GACGTTTAACGATAGCTTTGATATGGAGATCAGGGAAACAGAGATTGCTCTGATCCCCAAGAAAAAGCCCAAATACCAAT
TTACTCTGGATGAGTTGCTCGAAGGGATGACGCCTGAACATGTCCATGAGAAAGTTGATTTTGGTGCACCCGTAGGCAAG
GAGCTGCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7T5U8Q8