Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1716162..1716715 Replicon chromosome
Accession NZ_CP024842
Organism Pectobacterium versatile strain 3-2

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0H3I1X4
Locus tag OA04_RS07740 Protein ID WP_014699358.1
Coordinates 1716401..1716715 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3I2T3
Locus tag OA04_RS07735 Protein ID WP_014699357.1
Coordinates 1716162..1716398 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OA04_RS07725 1712893..1714050 + 1158 WP_014699355.1 PD-(D/E)XK nuclease family protein -
OA04_RS07730 1714899..1715843 + 945 WP_014699356.1 DUF1738 domain-containing protein -
OA04_RS07735 1716162..1716398 + 237 WP_014699357.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OA04_RS07740 1716401..1716715 + 315 WP_014699358.1 CcdB family protein Toxin
OA04_RS07750 1716963..1717367 - 405 WP_107333697.1 hypothetical protein -
OA04_RS07755 1717405..1717953 - 549 WP_107332618.1 hypothetical protein -
OA04_RS07760 1718335..1719492 + 1158 WP_107332619.1 hypothetical protein -
OA04_RS07765 1719659..1720405 - 747 WP_107332620.1 molybdopterin-guanine dinucleotide biosynthesis protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1699718..1741130 41412


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11545.51 Da        Isoelectric Point: 7.9859

>T88804 WP_014699358.1 NZ_CP024842:1716401-1716715 [Pectobacterium versatile]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPLQTLG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T88804 NZ_CP024842:1716401-1716715 [Pectobacterium versatile]
ATGCAATTCACTGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAATTGAATCGTCGGATAGTGATCCCATTGCTCCCTATTGAAAAGTATCCGGCAGGCCGCCGACCGGATCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACGCACGAGCTGGCAAGTATTCCTCTCCAGACTCTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCCATCGATTTCCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9004.06 Da        Isoelectric Point: 6.4610

>AT88804 WP_014699357.1 NZ_CP024842:1716162-1716398 [Pectobacterium versatile]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRYHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp

>AT88804 NZ_CP024842:1716162-1716398 [Pectobacterium versatile]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACAGTAGAGCGTGCCTTACTGGTAAGAGCGCGTGAGGCGGG
TATTAATCTGAGTGCTACCCTGACAACCGCCCTGGATGCAGAGCTTCGCTATCATGAAGCGAAAAAATGGCAAGAAGAAA
ACAGAGAGGCTCTCGCAGCACTAAATCGTTTTCATGATGAACAGGGTTGTTTCAGTGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3I1X4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I2T3

References