Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1323284..1323909 Replicon chromosome
Accession NZ_CP024842
Organism Pectobacterium versatile strain 3-2

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag OA04_RS05960 Protein ID WP_005976087.1
Coordinates 1323284..1323487 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag OA04_RS05965 Protein ID WP_005976089.1
Coordinates 1323541..1323909 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OA04_RS05930 1318743..1319081 + 339 WP_002208627.1 P-II family nitrogen regulator -
OA04_RS05935 1319121..1320407 + 1287 WP_191089095.1 ammonium transporter AmtB -
OA04_RS05940 1320543..1321406 - 864 WP_105879273.1 acyl-CoA thioesterase II -
OA04_RS05945 1321619..1322200 + 582 WP_039490514.1 YbaY family lipoprotein -
OA04_RS05950 1322220..1322540 - 321 WP_015839360.1 MGMT family protein -
OA04_RS05960 1323284..1323487 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
OA04_RS05965 1323541..1323909 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
OA04_RS05970 1324507..1324650 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
OA04_RS05975 1324667..1324915 - 249 WP_039506474.1 type B 50S ribosomal protein L31 -
OA04_RS05980 1325151..1328279 - 3129 WP_103862997.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T88802 WP_005976087.1 NZ_CP024842:c1323487-1323284 [Pectobacterium versatile]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T88802 NZ_CP024842:c1323487-1323284 [Pectobacterium versatile]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGTCTGGCTGAACTGACAATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT88802 WP_005976089.1 NZ_CP024842:c1323909-1323541 [Pectobacterium versatile]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT88802 NZ_CP024842:c1323909-1323541 [Pectobacterium versatile]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTATGTGACGAAAGCATAGC
AACGTTAGGTGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGAATTAATGATGCTGAACTGCGGCGTTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References