Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 444447..445039 Replicon chromosome
Accession NZ_CP024842
Organism Pectobacterium versatile strain 3-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OA04_RS02015 Protein ID WP_103971367.1
Coordinates 444447..444701 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OA04_RS02020 Protein ID WP_095701362.1
Coordinates 444698..445039 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OA04_RS01995 439537..440088 + 552 WP_095701360.1 polymer-forming cytoskeletal protein -
OA04_RS02000 440287..441462 + 1176 WP_103860383.1 IS4 family transposase -
OA04_RS02005 441493..444135 + 2643 Protein_377 CRISPR-associated helicase Cas3' -
OA04_RS02015 444447..444701 + 255 WP_103971367.1 type II toxin-antitoxin system HicA family toxin Toxin
OA04_RS02020 444698..445039 + 342 WP_095701362.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OA04_RS22755 445451..445630 + 180 WP_130623304.1 hypothetical protein -
OA04_RS02025 445670..447238 + 1569 WP_107332209.1 type I-E CRISPR-associated protein Cse1/CasA -
OA04_RS02030 447222..447869 + 648 WP_107332210.1 type I-E CRISPR-associated protein Cse2/CasB -
OA04_RS02035 447873..448937 + 1065 WP_103861596.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
OA04_RS02040 448947..449681 + 735 WP_107332211.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 440287..441462 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9612.09 Da        Isoelectric Point: 11.2749

>T88796 WP_103971367.1 NZ_CP024842:444447-444701 [Pectobacterium versatile]
MNKRHQRTLSDLFSRPVNSSIKWSDIESLFIALGAEIHEREGSRIAVLLKGEKKIFHRPHPRPTTDKGAVNSIRVWLESL
GVRP

Download         Length: 255 bp

>T88796 NZ_CP024842:444447-444701 [Pectobacterium versatile]
ATGAATAAACGACACCAAAGAACGCTATCAGATCTGTTTTCTCGTCCAGTTAATAGTTCAATAAAATGGAGCGATATAGA
ATCTCTTTTTATTGCACTAGGGGCTGAAATTCATGAAAGGGAAGGTTCGAGGATTGCGGTATTGTTGAAAGGTGAGAAAA
AAATTTTTCATCGACCACATCCCAGACCGACTACTGACAAAGGAGCGGTTAACTCTATTCGGGTATGGTTAGAAAGTTTA
GGAGTAAGACCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12384.98 Da        Isoelectric Point: 4.4547

>AT88796 WP_095701362.1 NZ_CP024842:444698-445039 [Pectobacterium versatile]
MINTLLIDGHTAVIAFDSEIEMFRGEFIGLNGGADFYAYSVDELKKEGATSLAIFLDECRRDGIEPYKSYSGKVTTRLTP
ERHAALAVTAQATGVSINELLNEGVDLVLERRS

Download         Length: 342 bp

>AT88796 NZ_CP024842:444698-445039 [Pectobacterium versatile]
ATGATTAACACACTTCTTATCGACGGTCACACGGCCGTTATTGCTTTTGACTCGGAAATTGAAATGTTCCGGGGAGAATT
CATTGGCTTGAATGGCGGCGCTGATTTTTATGCTTACAGTGTTGATGAGCTGAAAAAAGAAGGGGCAACCTCTCTCGCTA
TTTTTCTTGATGAATGCCGCCGTGATGGTATTGAACCCTATAAATCCTACAGTGGAAAAGTCACAACACGTTTGACGCCA
GAACGTCATGCTGCGCTGGCGGTAACGGCGCAAGCAACTGGAGTTTCCATTAACGAATTGTTAAACGAAGGTGTCGATCT
GGTTCTTGAACGACGCTCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References