Detailed information of TA system TA088710

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 100333..101167
• Replicon: chromosome
• Accession: NZ_CP024830
• Organism: Escherichia coli strain CREC-532

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B7MK10
• Locus tag: CU076_RS00600
• Protein ID: WP_000854820.1
• Coordinates: 100790..101167 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: CU076_RS00595
• Protein ID: WP_001285610.1
• Coordinates: 100333..100701 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CU076_RS00560	96054..96734	+	681	WP_001278649.1	WYL domain-containing protein	-
CU076_RS00565	96885..97562	+	678	WP_001097565.1	hypothetical protein	-
CU076_RS00570	97568..97801	+	234	WP_000883181.1	DUF905 family protein	-
CU076_RS00575	97891..98709	+	819	WP_001175155.1	DUF945 domain-containing protein	-
CU076_RS00580	98975..99454	+	480	WP_000706978.1	antirestriction protein	-
CU076_RS00585	99469..99945	+	477	WP_001186193.1	RadC family protein	-
CU076_RS00590	100032..100253	+	222	WP_000692347.1	DUF987 domain-containing protein	-
CU076_RS00595	100333..100701	+	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CU076_RS00600	100790..101167	+	378	WP_000854820.1	type IV toxin-antitoxin system toxin CbtA	Toxin
CU076_RS27290	101164..101361	+	198	Protein_106	hypothetical protein	-
CU076_RS00605	101389..101586	+	198	WP_085949158.1	DUF957 domain-containing protein	-
CU076_RS00610	101671..102231	+	561	Protein_108	DUF4942 domain-containing protein	-
CU076_RS00615	102598..103134	-	537	WP_000942785.1	GspM family type II secretion system protein YghD	-
CU076_RS00620	103136..104314	-	1179	WP_000094991.1	type II secretion system protein GspL	-
CU076_RS00625	104311..105288	-	978	WP_000633209.1	type II secretion system minor pseudopilin GspK	-
CU076_RS00630	105291..105890	-	600	WP_001255034.1	type II secretion system minor pseudopilin GspJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14043.12 Da
• Isoelectric Point: 7.8839

>T88710 WP_000854820.1 NZ_CP024830:100790-101167 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Nucleotide

• Length: 378 bp

>T88710 NZ_CP024830:100790-101167 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT88710 WP_001285610.1 NZ_CP024830:100333-100701 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT88710 NZ_CP024830:100333-100701 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGTACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0E2KXX6