Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3748512..3749353 Replicon chromosome
Accession NZ_CP024821
Organism Escherichia coli strain CREC-591

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag CU078_RS19810 Protein ID WP_000854822.1
Coordinates 3748970..3749353 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A243ZR83
Locus tag CU078_RS19805 Protein ID WP_071587515.1
Coordinates 3748512..3748880 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU078_RS19785 3746256..3747074 + 819 WP_001234702.1 DUF945 domain-containing protein -
CU078_RS19790 3747165..3747650 + 486 WP_063097556.1 antirestriction protein -
CU078_RS19795 3747666..3748142 + 477 WP_001186740.1 RadC family protein -
CU078_RS19800 3748211..3748432 + 222 WP_000692312.1 DUF987 domain-containing protein -
CU078_RS19805 3748512..3748880 + 369 WP_071587515.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CU078_RS19810 3748970..3749353 + 384 WP_000854822.1 type IV toxin-antitoxin system toxin CbtA Toxin
CU078_RS19815 3749344..3749832 + 489 WP_001177592.1 hypothetical protein -
CU078_RS19820 3749844..3750041 + 198 WP_000839263.1 DUF957 domain-containing protein -
CU078_RS19825 3750138..3750983 + 846 WP_072735927.1 DUF4942 domain-containing protein -
CU078_RS19835 3751282..3751788 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
CU078_RS19840 3751866..3753707 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T88653 WP_000854822.1 NZ_CP024821:3748970-3749353 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T88653 NZ_CP024821:3748970-3749353 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13631.41 Da        Isoelectric Point: 6.6244

>AT88653 WP_071587515.1 NZ_CP024821:3748512-3748880 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT88653 NZ_CP024821:3748512-3748880 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A243ZR83

References