Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3273768..3274507 Replicon chromosome
Accession NZ_CP024812
Organism Enterobacter sp. CRENT-193

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag CU081_RS16335 Protein ID WP_003857133.1
Coordinates 3274022..3274507 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag CU081_RS16330 Protein ID WP_003857131.1
Coordinates 3273768..3274034 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU081_RS16310 3269244..3270230 + 987 WP_022651202.1 DUF979 domain-containing protein -
CU081_RS16315 3270240..3271235 + 996 WP_003857125.1 DUF2891 domain-containing protein -
CU081_RS16320 3271257..3272645 - 1389 WP_032645625.1 MFS transporter -
CU081_RS16325 3272775..3273704 + 930 WP_022651200.1 LysR family transcriptional regulator -
CU081_RS16330 3273768..3274034 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
CU081_RS16335 3274022..3274507 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
CU081_RS16340 3274882..3275361 + 480 WP_001542736.1 hypothetical protein -
CU081_RS16345 3275383..3276186 + 804 WP_039268887.1 TIGR02391 family protein -
CU081_RS16350 3276207..3277640 + 1434 WP_004016055.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T88577 WP_003857133.1 NZ_CP024812:3274022-3274507 [Enterobacter sp. CRENT-193]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T88577 NZ_CP024812:3274022-3274507 [Enterobacter sp. CRENT-193]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACCTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGGAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCAGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT88577 WP_003857131.1 NZ_CP024812:3273768-3274034 [Enterobacter sp. CRENT-193]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT88577 NZ_CP024812:3273768-3274034 [Enterobacter sp. CRENT-193]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCGGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References