Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1662191..1662848 Replicon chromosome
Accession NZ_CP024812
Organism Enterobacter sp. CRENT-193

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag CU081_RS08225 Protein ID WP_022649305.1
Coordinates 1662438..1662848 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag CU081_RS08220 Protein ID WP_003863437.1
Coordinates 1662191..1662457 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU081_RS08200 1657623..1659056 - 1434 WP_022651811.1 6-phospho-beta-glucosidase BglA -
CU081_RS08205 1659173..1659904 - 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
CU081_RS08210 1660171..1660830 + 660 WP_003863433.1 hemolysin III family protein -
CU081_RS08215 1660916..1661896 - 981 WP_003863435.1 tRNA-modifying protein YgfZ -
CU081_RS08220 1662191..1662457 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
CU081_RS08225 1662438..1662848 + 411 WP_022649305.1 protein YgfX Toxin
CU081_RS08230 1662850..1663371 - 522 WP_003863440.1 flavodoxin FldB -
CU081_RS08235 1663473..1664369 + 897 WP_022651809.1 site-specific tyrosine recombinase XerD -
CU081_RS08240 1664398..1665111 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CU081_RS08245 1665117..1666850 + 1734 WP_022651808.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T88567 WP_022649305.1 NZ_CP024812:1662438-1662848 [Enterobacter sp. CRENT-193]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T88567 NZ_CP024812:1662438-1662848 [Enterobacter sp. CRENT-193]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT88567 WP_003863437.1 NZ_CP024812:1662191-1662457 [Enterobacter sp. CRENT-193]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT88567 NZ_CP024812:1662191-1662457 [Enterobacter sp. CRENT-193]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References