Detailed information of TA system TA088563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1936000..1937027
• Replicon: chromosome
• Accession: NZ_CP024811
• Organism: Halomonas alkaliphila strain X3

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: CUU95_RS08945
• Protein ID: WP_120386310.1
• Coordinates: 1936455..1937027 (+)
• Length: 191 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: CUU95_RS08940
• Protein ID: WP_095603744.1
• Coordinates: 1936000..1936455 (+)
• Length: 152 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUU95_RS08920	1932287..1933261	+	975	WP_120386307.1	class I SAM-dependent methyltransferase	-
CUU95_RS08925	1933263..1933724	+	462	WP_120386308.1	adenylyltransferase/cytidyltransferase family protein	-
CUU95_RS08935	1935200..1935799	+	600	WP_120386309.1	hypothetical protein	-
CUU95_RS08940	1936000..1936455	+	456	WP_095603744.1	helix-turn-helix domain-containing protein	Antitoxin
CUU95_RS08945	1936455..1937027	+	573	WP_120386310.1	PIN domain-containing protein	Toxin
CUU95_RS08950	1937267..1938037	+	771	WP_120386311.1	amino acid ABC transporter substrate-binding protein	-
CUU95_RS08955	1938128..1938802	+	675	WP_193060826.1	amino acid ABC transporter permease	-
CUU95_RS08960	1938799..1939554	+	756	WP_120386312.1	amino acid ABC transporter ATP-binding protein	-
CUU95_RS08965	1939828..1940094	+	267	WP_009722795.1	30S ribosomal protein S20	-
CUU95_RS08970	1940204..1941781	+	1578	WP_120386313.1	murein biosynthesis integral membrane protein MurJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-114)

Antitoxin

• Helix-turn-helix domain, group 17 (81-126)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 21854.08 Da
• Isoelectric Point: 6.0105

>T88563 WP_120386310.1 NZ_CP024811:1936455-1937027 [Halomonas alkaliphila]
MSSCYTVVYDACVLYPAPLRSFLIHLAMTDLYRARWSQLIHDEWMRNLLEQRSDLTWAQLERVRDLMDKHTRDAVVSGFE
PLIDGLLLPDPDDRHVLACAIHSGAEAIITFNLKDFPDHALAQYDIRAIHPDEFISDMLALSPGHVVQAVQNHRKSLKKP
PFSISEYLDLLFNQRLPESVSELRRFGSLL

Nucleotide

• Length: 573 bp

>T88563 NZ_CP024811:1936455-1937027 [Halomonas alkaliphila]
ATGAGTTCTTGCTACACTGTCGTATACGATGCATGTGTGCTTTATCCAGCCCCGCTAAGAAGTTTTTTGATTCACTTGGC
TATGACGGATCTTTATCGAGCACGCTGGTCGCAACTAATCCATGACGAATGGATGCGTAATCTATTGGAGCAACGTAGCG
ACTTAACTTGGGCGCAGTTGGAGCGTGTTCGTGACTTGATGGATAAGCACACACGAGATGCGGTGGTATCAGGGTTTGAG
CCATTGATTGATGGGTTATTGCTTCCCGATCCAGATGACCGTCATGTGCTGGCCTGTGCTATTCATAGCGGTGCAGAAGC
TATCATTACGTTTAACTTAAAGGATTTTCCTGATCATGCTTTAGCACAATACGATATTAGGGCAATACATCCTGATGAAT
TCATTTCGGATATGTTGGCCTTGAGCCCAGGGCATGTTGTCCAAGCCGTTCAAAATCATCGTAAAAGCCTAAAAAAACCA
CCTTTTAGTATCAGTGAATATCTAGACTTGCTGTTTAATCAAAGACTTCCCGAGTCAGTGAGTGAGTTAAGGCGCTTTGG
GTCGCTGCTTTAG

Antitoxin

Protein

• Length: 152 a.a.
• Molecular weight: 16694.08 Da
• Isoelectric Point: 6.2256

>AT88563 WP_095603744.1 NZ_CP024811:1936000-1936455 [Halomonas alkaliphila]
MGSLSNLLPSQEEAALAKLSSRELAAHVETRASTQHVAITDKDGHIHQVEVPVSALRLLIDILTELGDGNTVKLIPVHAE
MTTQEAADVLNMSRPTLIKVLDEGRIPYHRAGNRRKLKYTDVMAYKTSVDQKRLQVLEELSELDQSLGLGY

Nucleotide

• Length: 456 bp

>AT88563 NZ_CP024811:1936000-1936455 [Halomonas alkaliphila]
ATGGGATCGTTGTCTAATTTGCTACCTAGCCAAGAAGAGGCTGCTCTGGCTAAGCTCTCCAGTCGTGAACTTGCGGCACA
TGTTGAAACGCGAGCTTCCACACAACATGTCGCTATTACTGATAAAGATGGGCATATTCATCAAGTTGAAGTCCCTGTGA
GTGCTTTGCGCCTGCTGATCGATATTTTGACCGAGCTCGGTGATGGTAATACGGTAAAGCTAATTCCTGTTCATGCTGAA
ATGACCACTCAGGAGGCGGCGGATGTGCTCAACATGTCACGACCGACATTAATTAAAGTGCTGGATGAAGGAAGAATTCC
TTATCATCGTGCTGGAAATCGGCGAAAACTCAAATACACCGATGTGATGGCTTATAAAACCAGCGTAGATCAAAAACGTT
TGCAAGTACTTGAGGAGTTGTCGGAGCTCGATCAGTCGCTGGGTCTGGGGTATTGA