Detailed information of TA system TA088560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 452267..452925
• Replicon: chromosome
• Accession: NZ_CP024811
• Organism: Halomonas alkaliphila strain X3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CUU95_RS02150
• Protein ID: WP_120385665.1
• Coordinates: 452267..452683 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CUU95_RS02155
• Protein ID: WP_205739031.1
• Coordinates: 452680..452925 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUU95_RS02130	447658..449031	+	1374	WP_120385661.1	AAA family ATPase	-
CUU95_RS02135	449015..449647	+	633	WP_120385662.1	TIGR02646 family protein	-
CUU95_RS02140	449768..450709	-	942	WP_205739016.1	DUF808 family protein	-
CUU95_RS02145	450856..451989	-	1134	WP_120385664.1	Fic family protein	-
CUU95_RS02150	452267..452683	-	417	WP_120385665.1	type II toxin-antitoxin system VapC family toxin	Toxin
CUU95_RS02155	452680..452925	-	246	WP_205739031.1	Arc family DNA-binding protein	Antitoxin
CUU95_RS02160	453318..454541	+	1224	WP_120385667.1	hypothetical protein	-
CUU95_RS02170	455020..456957	+	1938	WP_120385669.1	DUF3732 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (6-43)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14805.85 Da
• Isoelectric Point: 4.5482

>T88560 WP_120385665.1 NZ_CP024811:c452683-452267 [Halomonas alkaliphila]
MIVLDTNVVSEAMKPESDPAVRAWLNEQSAETLYLSSVTRTELLFGIAALPNGKRKDMLSEVLGGLTELFRGRILSFDAD
AAHKYAELAVTARTTGRGFPVPDGYIAAIAVSQGYQVASRDMSPFEAANVAVINPCEA

Nucleotide

• Length: 417 bp

>T88560 NZ_CP024811:c452683-452267 [Halomonas alkaliphila]
ATGATCGTTCTGGATACCAATGTCGTTTCCGAGGCGATGAAACCCGAGTCTGATCCGGCCGTCAGAGCTTGGCTGAATGA
GCAGTCGGCAGAAACGTTATACCTGTCTAGTGTCACTCGGACTGAGTTGTTATTTGGTATTGCGGCGCTGCCCAACGGGA
AGCGTAAGGACATGTTGAGCGAGGTCTTGGGCGGTCTTACTGAGCTGTTCAGAGGGCGGATTTTGTCTTTCGACGCTGAC
GCCGCTCACAAGTATGCCGAGCTGGCTGTGACGGCTAGAACCACCGGGCGGGGTTTTCCTGTGCCGGATGGCTACATTGC
AGCTATTGCCGTATCACAAGGCTATCAAGTCGCATCCCGTGATATGTCCCCATTTGAGGCGGCCAATGTGGCCGTCATTA
ATCCATGTGAGGCTTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9129.33 Da
• Isoelectric Point: 5.7303

>AT88560 WP_205739031.1 NZ_CP024811:c452925-452680 [Halomonas alkaliphila]
MNIRSIPDEVHNALKARAKQNHRSAEDEVRAILEEATRPECRLKMGDALTDLSRKVGVANEDVAIFEQVQGKTPAEPMRF
E

Nucleotide

• Length: 246 bp

>AT88560 NZ_CP024811:c452925-452680 [Halomonas alkaliphila]
ATGAATATCAGAAGCATCCCTGACGAAGTACACAATGCACTGAAAGCGCGCGCTAAGCAGAATCATCGCAGCGCCGAGGA
TGAGGTGCGGGCCATTCTGGAAGAGGCCACACGGCCAGAATGTCGTCTAAAAATGGGTGATGCTCTGACGGATTTGAGCC
GCAAGGTGGGGGTGGCCAATGAAGACGTTGCTATCTTTGAACAGGTGCAAGGCAAGACACCGGCTGAACCGATGAGGTTT
GAATGA