88555

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2059647..2060115 Replicon chromosome
Accession NZ_CP024809
Organism Staphylococcus haemolyticus strain 83131A

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag CUZ62_RS09970 Protein ID WP_011276326.1
Coordinates 2059927..2060115 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID Q4L4Q5
Locus tag CUZ62_RS09965 Protein ID WP_011276325.1
Coordinates 2059647..2059904 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUZ62_RS09930 2054823..2055548 - 726 WP_033079650.1 type I 3-dehydroquinate dehydratase -
CUZ62_RS09935 2055711..2056133 + 423 WP_016931015.1 organic hydroperoxide resistance protein -
CUZ62_RS09940 2056396..2056887 + 492 WP_049395890.1 GNAT family N-acetyltransferase -
CUZ62_RS09945 2057019..2057636 + 618 WP_033079648.1 LysE/ArgO family amino acid transporter -
CUZ62_RS09950 2057823..2058431 - 609 WP_011276323.1 phosphoglycerate mutase family protein -
CUZ62_RS09955 2058659..2058901 + 243 WP_011276324.1 hypothetical protein -
CUZ62_RS09960 2058893..2059096 - 204 WP_033079647.1 sterile alpha motif-like domain-containing protein -
CUZ62_RS09965 2059647..2059904 + 258 WP_011276325.1 hypothetical protein Antitoxin
CUZ62_RS09970 2059927..2060115 + 189 WP_011276326.1 hypothetical protein Toxin
CUZ62_RS09975 2060233..2060814 + 582 WP_033079646.1 orthopoxovirus protein, PF05708 family -
CUZ62_RS09980 2060862..2061098 - 237 WP_016931008.1 hypothetical protein -
CUZ62_RS09985 2061268..2062014 + 747 WP_033079645.1 membrane lipoprotein lipid attachment site-containing protein -
CUZ62_RS09990 2062083..2062691 - 609 WP_033079644.1 GNAT family N-acetyltransferase -
CUZ62_RS09995 2062828..2063574 + 747 WP_033079643.1 poly-gamma-glutamate hydrolase family protein -
CUZ62_RS10000 2063650..2063937 + 288 WP_033079642.1 hypothetical protein -
CUZ62_RS10005 2064181..2064405 + 225 WP_033079641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T88555 WP_011276326.1 NZ_CP024809:2059927-2060115 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T88555 NZ_CP024809:2059927-2060115 [Staphylococcus haemolyticus]
ATGAGTTTGCATTTAACTATATTGTTATGGCTTGGTATCATTTTTGTAATAGCAGCCTCAATTATATTGGGCTTATTACT
TAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGTTTTACCGTAATATTTTATATTTTTGGATTTGCTTTACTCA
TCTACGTATTCATATTTGGTATATTATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9914.97 Da        Isoelectric Point: 4.0625

>AT88555 WP_011276325.1 NZ_CP024809:2059647-2059904 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Download         Length: 258 bp

>AT88555 NZ_CP024809:2059647-2059904 [Staphylococcus haemolyticus]
ATGAATAATAATAAAATTTTTTGGATAAATATTTTTATGACGCTATTATTTTTGGGTTTCAATATCATTGTCACTTACAA
TGCAGACTTAGATGATTTCTTCTGGCTAATTCCAGGACTGACAATTAGTGGTATCACAATTGTACTAAGCTTAAGTACTG
CGCTCATTTGCAAGAACCTGGTTAGCGAAGTTATTTTTCTAATCAATATTGTTATGCTTTTATACTACATTTATCCTATG
GTATATACATTCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1KAX9

References