Detailed information of TA system TA088554

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1076138..1076909
• Replicon: chromosome
• Accession: NZ_CP024809
• Organism: Staphylococcus haemolyticus strain 83131A

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: CUZ62_RS05295
• Protein ID: WP_011275410.1
• Coordinates: 1076760..1076909 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: CUZ62_RS05290
• Protein ID: WP_011275409.1
• Coordinates: 1076138..1076737 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUZ62_RS05270	1072021..1073475	+	1455	WP_033079569.1	ABC transporter substrate-binding protein/permease	-
CUZ62_RS05275	1073468..1074190	+	723	WP_016931345.1	amino acid ABC transporter ATP-binding protein	-
CUZ62_RS05280	1074368..1075495	+	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
CUZ62_RS05285	1075496..1075966	+	471	WP_016931343.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
CUZ62_RS05290	1076138..1076737	+	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
CUZ62_RS05295	1076760..1076909	+	150	WP_011275410.1	hypothetical protein	Toxin
CUZ62_RS05300	1077120..1077515	+	396	WP_011275411.1	hypothetical protein	-
CUZ62_RS05305	1077722..1079107	+	1386	WP_037571293.1	class II fumarate hydratase	-
CUZ62_RS05310	1079173..1079997	-	825	WP_011275413.1	RluA family pseudouridine synthase	-
CUZ62_RS05315	1080185..1081294	+	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	dfrG	gnd	1043985..1488272	444287

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T88554 WP_011275410.1 NZ_CP024809:1076760-1076909 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T88554 NZ_CP024809:1076760-1076909 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
CTTGGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAAGTTGAATCAATCGCATGAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT88554 WP_011275409.1 NZ_CP024809:1076138-1076737 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT88554 NZ_CP024809:1076138-1076737 [Staphylococcus haemolyticus]
ATGGCAATGAACTTTAAAGTATTTAATGATGTAGAACATGTAGCTGAGTACACAGCAGATATCATTAGAAAGCAATTTAA
TAATAACCCTACAACTATTGCGGGAATTCATTTAACAAAGGATGCTGCACCTGTTTTAGATGAGTTAAAGAAAGATGTAG
ATCATAATGCGGTTGATTTTAGTCAAGTAAATATCTTAGATTATGACGATAATCGCTCTTACTATGAAGCATTAGGTGTA
CCTGCTAGTCAAATTTATCCAATTAATCTTGACGATGATGCAGAATCTTTAATTGATGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTAATTTTACAAGTTACTTCTATTGATGAATCAGGTAGTTTAAATGTAAATGTAAGACAAGGATTATTAA
AAGCGCGTGAAGTAGTATTAGTTGTGACTGGTGCTAATAAACGTGAAGTTGTTAAAAAACTTTATGAAGAAAATGGTAAA
TCTAGCTTTGAACCATCTGATTTAAAAGCTCATAGAATGGTAACAGTTGTTTTAGATAGAGCAGCTGCAGAAGGTTTACC
TGAGGATGTTAAAGAATATTTCACTGCTAGATTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2