Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 932211..932743 Replicon chromosome
Accession NZ_CP024809
Organism Staphylococcus haemolyticus strain 83131A

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag CUZ62_RS04475 Protein ID WP_011275272.1
Coordinates 932378..932743 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag CUZ62_RS04470 Protein ID WP_011275271.1
Coordinates 932211..932381 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUZ62_RS04445 927998..928477 + 480 WP_011275266.1 PH domain-containing protein -
CUZ62_RS04450 928470..929993 + 1524 WP_016931363.1 PH domain-containing protein -
CUZ62_RS04455 929986..930512 + 527 Protein_878 PH domain-containing protein -
CUZ62_RS04460 930522..930881 + 360 WP_011275269.1 holo-ACP synthase -
CUZ62_RS04465 930977..932125 + 1149 WP_016931365.1 alanine racemase -
CUZ62_RS04470 932211..932381 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
CUZ62_RS04475 932378..932743 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CUZ62_RS04480 933051..934052 + 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
CUZ62_RS04485 934151..934477 + 327 WP_011275274.1 anti-sigma factor antagonist -
CUZ62_RS04490 934479..934958 + 480 WP_011275275.1 anti-sigma B factor RsbW -
CUZ62_RS04495 934933..935703 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T88553 WP_011275272.1 NZ_CP024809:932378-932743 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T88553 NZ_CP024809:932378-932743 [Staphylococcus haemolyticus]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTGTCACCAGTACAGGGCTCAGAACAAGGGGGAGTCAGACCTGTAGT
TATCATTCAAAACGATACTGGTAACAAATATAGTCCTACCGTAATCGTTGCTGCGATTACGGGAAGGATTAATAAAGCGA
AAATACCCACACATGTTGAAATCGAGAAAAAGAAATACAGACTTGATAAAGATTCAGTTATTCTACTCGAGCAAATTAGA
ACATTAGATAAAAAACGACTAAAAGAAAAATTAACATATCTATCTGATGAGAAAATGCAAGAAGTGGATGAAGCGTTAGA
CATTAGTCTAGGATTGCATGATGAAGTTAAAACGCAAAACACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT88553 WP_011275271.1 NZ_CP024809:932211-932381 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT88553 NZ_CP024809:932211-932381 [Staphylococcus haemolyticus]
ATGCTTACTTTCAATCAAAATAGAAGTCACAGTCTTGAACAATCTTTAAAAGAAGGCTATGCACAAATGGCCGAATTAAA
TCTCTCCCTAGCGACAGAAGCTTTTCCTCTAGAATGCGAAGCTTGTGATTGCAACGAAACGTACCTTATTTCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References