Detailed information of TA system TA088552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 919287..919798
• Replicon: chromosome
• Accession: NZ_CP024809
• Organism: Staphylococcus haemolyticus strain 83131A

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: CUZ62_RS04410
• Protein ID: WP_011275259.1
• Coordinates: 919592..919798 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: CUZ62_RS04405
• Protein ID: WP_011275258.1
• Coordinates: 919287..919580 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUZ62_RS04385	914442..915317	+	876	WP_011275255.1	membrane protein insertase YidC	-
CUZ62_RS04390	915512..916828	+	1317	WP_058646542.1	ISL3 family transposase	-
CUZ62_RS04395	916875..917516	-	642	WP_016931420.1	HD domain-containing protein	-
CUZ62_RS04400	917616..919100	-	1485	WP_011275257.1	cardiolipin synthase	-
CUZ62_RS04405	919287..919580	+	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
CUZ62_RS04410	919592..919798	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
CUZ62_RS04415	919906..920043	+	138	WP_011275260.1	hypothetical protein	-
CUZ62_RS04420	920340..922034	+	1695	WP_011275261.1	IS1182 family transposase	-
CUZ62_RS04425	921992..923191	-	1200	WP_048668183.1	rod shape-determining protein RodA	-
CUZ62_RS04430	923609..924679	+	1071	WP_011275263.1	D-alanine--D-alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	915512..922034	6522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T88552 WP_011275259.1 NZ_CP024809:919592-919798 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T88552 NZ_CP024809:919592-919798 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT88552 WP_011275258.1 NZ_CP024809:919287-919580 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT88552 NZ_CP024809:919287-919580 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8