Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2810725..2811569 Replicon chromosome
Accession NZ_CP024801
Organism Escherichia coli strain AMA1167

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag CUC42_RS14475 Protein ID WP_000854686.1
Coordinates 2810725..2811108 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag CUC42_RS14480 Protein ID WP_001285602.1
Coordinates 2811189..2811569 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC42_RS14435 2805728..2806219 - 492 WP_001297187.1 DUF1097 domain-containing protein -
CUC42_RS14440 2806321..2806875 - 555 WP_001001902.1 molecular chaperone YcdY -
CUC42_RS14445 2806899..2807636 - 738 WP_000283664.1 zinc-binding phosphatase -
CUC42_RS14450 2807691..2808629 - 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
CUC42_RS14460 2809100..2809941 - 842 Protein_2669 DUF4942 domain-containing protein -
CUC42_RS14465 2810026..2810223 - 198 WP_000839253.1 DUF957 domain-containing protein -
CUC42_RS14470 2810240..2810728 - 489 WP_032180032.1 hypothetical protein -
CUC42_RS14475 2810725..2811108 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
CUC42_RS14480 2811189..2811569 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CUC42_RS14485 2811580..2812263 - 684 WP_000086768.1 hypothetical protein -
CUC42_RS14490 2812282..2812503 - 222 WP_000692298.1 DUF987 domain-containing protein -
CUC42_RS14495 2812566..2813042 - 477 WP_001186726.1 RadC family protein -
CUC42_RS14500 2813058..2813543 - 486 WP_000214307.1 antirestriction protein -
CUC42_RS14505 2813635..2814456 - 822 WP_001761104.1 DUF945 domain-containing protein -
CUC42_RS25715 2814557..2814765 - 209 Protein_2679 DUF905 domain-containing protein -
CUC42_RS14515 2814866..2815321 - 456 WP_000581506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T88542 WP_000854686.1 NZ_CP024801:c2811108-2810725 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T88542 NZ_CP024801:c2811108-2810725 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT88542 WP_001285602.1 NZ_CP024801:c2811569-2811189 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT88542 NZ_CP024801:c2811569-2811189 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References