Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49342..50143 Replicon chromosome
Accession NZ_CP024801
Organism Escherichia coli strain AMA1167

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag CUC42_RS00290 Protein ID WP_001094437.1
Coordinates 49342..49719 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag CUC42_RS00295 Protein ID WP_001390338.1
Coordinates 49766..50143 (-) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC42_RS00255 44699..45622 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
CUC42_RS00260 45733..46917 - 1185 WP_001172877.1 sugar efflux transporter -
CUC42_RS00265 47347..47475 - 129 Protein_47 virulence RhuM family protein -
CUC42_RS00275 47710..48555 - 846 WP_001274561.1 DUF4942 domain-containing protein -
CUC42_RS00280 48640..48837 - 198 WP_000772032.1 DUF957 domain-containing protein -
CUC42_RS00285 48857..49345 - 489 WP_000761716.1 hypothetical protein -
CUC42_RS00290 49342..49719 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
CUC42_RS00295 49766..50143 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CUC42_RS00300 50306..50527 - 222 WP_000692345.1 DUF987 domain-containing protein -
CUC42_RS00305 50590..51036 - 447 WP_089455113.1 RadC family protein -
CUC42_RS00310 51124..51870 - 747 WP_053906593.1 IS21-like element ISEc12 family helper ATPase IstB -
CUC42_RS00315 51885..53426 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
CUC42_RS00320 53668..53838 - 171 Protein_57 antirestriction protein -
CUC42_RS00325 53840..54604 - 765 Protein_58 autotransporter adhesin family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T88524 WP_001094437.1 NZ_CP024801:c49719-49342 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T88524 NZ_CP024801:c49719-49342 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT88524 WP_001390338.1 NZ_CP024801:c50143-49766 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT88524 NZ_CP024801:c50143-49766 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References