Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 8084212..8084789 Replicon chromosome
Accession NZ_CP024785
Organism Nostoc flagelliforme CCNUN1

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag COO91_RS37760 Protein ID WP_208766826.1
Coordinates 8084212..8084535 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag COO91_RS37765 Protein ID WP_100902597.1
Coordinates 8084529..8084789 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COO91_RS37740 8079935..8081980 + 2046 WP_100902593.1 5'-nucleotidase C-terminal domain-containing protein -
COO91_RS37745 8082027..8082746 + 720 WP_100902594.1 pyridoxine 5'-phosphate synthase -
COO91_RS37750 8082857..8083402 + 546 WP_100902595.1 dual specificity protein phosphatase family protein -
COO91_RS37755 8083446..8084135 + 690 WP_100902596.1 SAM-dependent methyltransferase -
COO91_RS37760 8084212..8084535 - 324 WP_208766826.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
COO91_RS37765 8084529..8084789 - 261 WP_100902597.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
COO91_RS37770 8084993..8085175 - 183 Protein_7439 hypothetical protein -
COO91_RS37775 8085262..8085507 + 246 WP_100903255.1 UPF0175 family protein -
COO91_RS37780 8085504..8085992 + 489 WP_100902598.1 DUF3368 domain-containing protein -
COO91_RS37785 8086237..8087088 + 852 WP_100902599.1 ATP-binding cassette domain-containing protein -
COO91_RS37790 8087045..8087899 + 855 WP_100902600.1 ABC transporter permease -
COO91_RS37795 8087919..8088392 + 474 WP_100902601.1 MarR family transcriptional regulator -
COO91_RS37800 8088358..8089638 + 1281 WP_100902602.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-105)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11928.81 Da        Isoelectric Point: 5.1066

>T88519 WP_208766826.1 NZ_CP024785:c8084535-8084212 [Nostoc flagelliforme CCNUN1]
VVVNRFDVFLVNLDPTIGSEIQKTRPCVVISPDEMNKYIATVIVAPMTTKGQSYPTRVACQFQGKDGQIVLDQIRTVDKT
RLVKKLGQIDSDEQKAVLDTLAEMFAE

Download         Length: 324 bp

>T88519 NZ_CP024785:c8084535-8084212 [Nostoc flagelliforme CCNUN1]
GTGGTAGTCAATCGATTTGATGTGTTTTTGGTTAACCTCGACCCAACCATTGGCAGTGAGATTCAAAAGACAAGACCTTG
TGTAGTAATTTCACCAGATGAGATGAATAAATATATTGCCACGGTTATTGTTGCTCCGATGACAACTAAAGGACAGTCTT
ATCCGACTCGTGTTGCTTGTCAGTTTCAGGGTAAAGATGGGCAAATCGTTCTAGATCAAATTCGTACAGTTGACAAAACT
CGATTAGTCAAAAAGCTAGGTCAGATTGACTCTGATGAACAAAAAGCAGTTTTAGATACTTTAGCTGAAATGTTTGCAGA
ATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9842.07 Da        Isoelectric Point: 4.6742

>AT88519 WP_100902597.1 NZ_CP024785:c8084789-8084529 [Nostoc flagelliforme CCNUN1]
MGTAIRTRIVKIGNSQGIRIPKLLLEQSGIGEEVEIEIQDCHLIVRAASQSRKGWDEAFARMAKQHDDALLDDGVTTEWE
HQEWEW

Download         Length: 261 bp

>AT88519 NZ_CP024785:c8084789-8084529 [Nostoc flagelliforme CCNUN1]
ATGGGGACAGCAATTAGAACCCGTATTGTTAAAATCGGGAATTCTCAAGGTATCCGCATTCCTAAACTTCTGCTGGAACA
AAGTGGTATTGGTGAAGAGGTGGAAATTGAAATTCAAGATTGTCACTTAATTGTCCGTGCTGCCTCTCAATCGCGTAAGG
GGTGGGATGAAGCATTTGCAAGAATGGCAAAGCAACACGATGATGCACTGCTCGATGATGGCGTAACTACAGAGTGGGAG
CATCAAGAGTGGGAGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References