Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 5882536..5883165 Replicon chromosome
Accession NZ_CP024785
Organism Nostoc flagelliforme CCNUN1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag COO91_RS27155 Protein ID WP_100901054.1
Coordinates 5882764..5883165 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag COO91_RS27150 Protein ID WP_100901053.1
Coordinates 5882536..5882763 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COO91_RS27130 5877770..5878855 + 1086 WP_100901050.1 glycosyltransferase family 4 protein -
COO91_RS27135 5878933..5880564 - 1632 WP_100901051.1 helix-hairpin-helix domain-containing protein -
COO91_RS27140 5880849..5882018 + 1170 WP_100903133.1 cysteine desulfurase -
COO91_RS27145 5882061..5882498 + 438 WP_100901052.1 hypothetical protein -
COO91_RS27150 5882536..5882763 + 228 WP_100901053.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
COO91_RS27155 5882764..5883165 + 402 WP_100901054.1 type II toxin-antitoxin system VapC family toxin Toxin
COO91_RS27160 5883263..5883997 + 735 WP_100901055.1 DUF1995 family protein -
COO91_RS27165 5884250..5884495 - 246 WP_100901056.1 hypothetical protein -
COO91_RS49760 5884572..5884730 + 159 WP_157816629.1 hypothetical protein -
COO91_RS27170 5884779..5887796 - 3018 WP_100901057.1 zinc-dependent metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14960.39 Da        Isoelectric Point: 6.9776

>T88516 WP_100901054.1 NZ_CP024785:5882764-5883165 [Nostoc flagelliforme CCNUN1]
MRYLFDTNICIYLIKQKPQKVLDKFQTLNISDVGISSITVAELEYGVAKSQQQQKNRTALLQFLLPLEIVEFNQASATIY
GSIRSNLESRGLIIGAMDMLIASHALSLGVTLVTNNVREFSRIPTVLLENWVE

Download         Length: 402 bp

>T88516 NZ_CP024785:5882764-5883165 [Nostoc flagelliforme CCNUN1]
ATGCGATACCTGTTTGATACGAACATCTGCATTTACCTGATAAAGCAAAAACCCCAAAAAGTACTGGATAAATTCCAAAC
CCTTAATATTTCTGATGTCGGTATCTCCTCCATCACCGTTGCCGAACTCGAATATGGAGTCGCCAAAAGCCAACAGCAAC
AGAAAAACCGCACCGCCCTGCTGCAATTTCTGCTACCTCTAGAAATTGTCGAATTCAATCAAGCATCTGCGACAATTTAC
GGCAGTATCAGAAGCAATCTAGAAAGTAGAGGACTTATTATTGGTGCAATGGATATGCTGATTGCTTCTCATGCGCTGAG
TTTAGGAGTTACCCTCGTCACCAATAATGTGCGAGAGTTTTCTCGTATTCCTACGGTCCTATTAGAAAACTGGGTTGAGT
AG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8515.65 Da        Isoelectric Point: 4.2975

>AT88516 WP_100901053.1 NZ_CP024785:5882536-5882763 [Nostoc flagelliforme CCNUN1]
MNTAKVTTDGTHQIVILPEDFQLTGTEVYIKKIGTVIVLIAKDNPWQSLIESLDNFSDDFMKSRDQPVIDTRESF

Download         Length: 228 bp

>AT88516 NZ_CP024785:5882536-5882763 [Nostoc flagelliforme CCNUN1]
ATGAACACTGCCAAAGTCACCACTGATGGTACTCACCAAATCGTTATTTTGCCCGAAGACTTTCAACTCACTGGTACTGA
AGTTTATATCAAAAAAATTGGCACCGTCATTGTCCTCATTGCCAAAGATAACCCCTGGCAATCCCTAATAGAGAGTCTAG
ACAATTTCTCCGATGACTTCATGAAGTCTAGAGATCAGCCAGTTATTGACACTAGAGAAAGTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References