Detailed information of TA system TA088515

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 5466172..5466609
• Replicon: chromosome
• Accession: NZ_CP024785
• Organism: Nostoc flagelliforme CCNUN1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: COO91_RS25385
• Protein ID: WP_100900779.1
• Coordinates: 5466385..5466609 (+)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: COO91_RS25380
• Protein ID: WP_100900778.1
• Coordinates: 5466172..5466381 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
COO91_RS25365	5462025..5463677	-	1653	WP_100900775.1	ferredoxin--nitrite reductase	-
COO91_RS25370	5464330..5464764	+	435	WP_100900776.1	ubiquinol-cytochrome c reductase iron-sulfur subunit	-
COO91_RS25375	5464782..5466080	+	1299	WP_100900777.1	HEAT repeat domain-containing protein	-
COO91_RS25380	5466172..5466381	+	210	WP_100900778.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
COO91_RS25385	5466385..5466609	+	225	WP_100900779.1	type II toxin-antitoxin system HicA family toxin	Toxin
COO91_RS25390	5466793..5467740	+	948	WP_100900780.1	LysR family transcriptional regulator	-
COO91_RS25395	5467869..5468942	+	1074	WP_100903105.1	anthranilate phosphoribosyltransferase family protein	-
COO91_RS25400	5469050..5470480	-	1431	WP_100900781.1	LCP family protein	-
COO91_RS25405	5470767..5471150	-	384	WP_100903106.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-65)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-51)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8481.70 Da
• Isoelectric Point: 10.2983

>T88515 WP_100900779.1 NZ_CP024785:5466385-5466609 [Nostoc flagelliforme CCNUN1]
MSNISVLKPQEVVRILENLGFVEVRQKGSHKQFRHQDGRGTTVPFHKSRDISPRLLRQIANDIGLSVEEMLESQ

Nucleotide

• Length: 225 bp

>T88515 NZ_CP024785:5466385-5466609 [Nostoc flagelliforme CCNUN1]
ATGAGCAACATTTCTGTCCTGAAGCCACAAGAGGTCGTCCGCATTCTAGAAAACCTTGGTTTTGTGGAGGTGCGCCAGAA
GGGTTCACACAAGCAGTTTCGTCACCAAGATGGTCGAGGAACAACAGTTCCGTTTCACAAAAGCCGTGATATTTCGCCGA
GATTGCTACGCCAAATTGCGAATGATATTGGTTTGTCTGTTGAAGAAATGCTGGAGTCGCAGTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7809.62 Da
• Isoelectric Point: 3.6566

>AT88515 WP_100900778.1 NZ_CP024785:5466172-5466381 [Nostoc flagelliforme CCNUN1]
MKTFTAIIERDSDTNLYVGYVPGFPGAHSQGETLDELQENLREVIEMLLEDEDATFETEFVGTQQIVVQ

Nucleotide

• Length: 210 bp

>AT88515 NZ_CP024785:5466172-5466381 [Nostoc flagelliforme CCNUN1]
ATGAAAACCTTTACTGCGATAATTGAGCGAGATTCTGATACTAATCTCTACGTTGGTTATGTGCCTGGATTTCCCGGAGC
GCATTCTCAAGGAGAAACCTTAGATGAGTTACAGGAAAATCTACGCGAAGTGATTGAGATGCTTCTAGAAGATGAAGACG
CGACATTTGAGACGGAATTTGTTGGTACACAGCAGATCGTGGTTCAGTAA