Detailed information of TA system TA088513

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 3946544..3946929
• Replicon: chromosome
• Accession: NZ_CP024785
• Organism: Nostoc flagelliforme CCNUN1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: COO91_RS18355
• Protein ID: WP_100899661.1
• Coordinates: 3946544..3946696 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: COO91_RS18360
• Protein ID: WP_100899662.1
• Coordinates: 3946708..3946929 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
COO91_RS18325	3942454..3942807	+	354	WP_100899656.1	phage holin family protein	-
COO91_RS18330	3942813..3943298	-	486	WP_100899657.1	cobalamin biosynthesis protein	-
COO91_RS18335	3943315..3943878	-	564	WP_100899658.1	Uma2 family endonuclease	-
COO91_RS18340	3944048..3945811	-	1764	WP_100899659.1	arginine--tRNA ligase	-
COO91_RS18350	3946123..3946470	-	348	WP_100899660.1	hypothetical protein	-
COO91_RS18355	3946544..3946696	+	153	WP_100899661.1	type II toxin-antitoxin system HicA family toxin	Toxin
COO91_RS18360	3946708..3946929	+	222	WP_100899662.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
COO91_RS18365	3946975..3948486	-	1512	WP_100899663.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
COO91_RS18370	3948571..3950721	-	2151	WP_100899664.1	glycine--tRNA ligase subunit beta	-
COO91_RS52240	3951168..3951452	+	285	WP_208766746.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-50)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5586.37 Da
• Isoelectric Point: 10.4691

>T88513 WP_100899661.1 NZ_CP024785:3946544-3946696 [Nostoc flagelliforme CCNUN1]
MHASLYLDRTKGSHRQFKHQGKPGLVTVPDKLSDDLAPGTLSSIWRQAQL

Nucleotide

• Length: 153 bp

>T88513 NZ_CP024785:3946544-3946696 [Nostoc flagelliforme CCNUN1]
TTGCATGCAAGTTTGTATCTTGATAGAACTAAAGGTAGTCATCGACAGTTCAAGCATCAGGGTAAACCAGGTTTAGTTAC
AGTTCCAGATAAATTGTCTGACGACTTAGCCCCTGGTACTCTTAGTAGTATTTGGAGGCAAGCACAGTTATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 7978.11 Da
• Isoelectric Point: 4.2243

>AT88513 WP_100899662.1 NZ_CP024785:3946708-3946929 [Nostoc flagelliforme CCNUN1]
MHYVVVIEKADSNYSAYVPDLPGCVTTGATLEEVKQMIAEAIEFHLEGMLEDGLPIPKPTSIAHEVEVAYSKT

Nucleotide

• Length: 222 bp

>AT88513 NZ_CP024785:3946708-3946929 [Nostoc flagelliforme CCNUN1]
ATGCATTACGTAGTGGTGATTGAAAAGGCGGATAGTAATTACTCTGCTTATGTTCCTGATTTACCAGGTTGTGTAACTAC
AGGTGCAACCTTAGAAGAAGTCAAGCAGATGATTGCAGAAGCTATTGAATTTCATTTAGAAGGAATGTTAGAAGATGGTT
TACCTATTCCTAAACCTACAAGCATCGCTCATGAAGTTGAAGTTGCATACAGCAAAACATAA