Detailed information of TA system TA088512

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 1712859..1713496
• Replicon: chromosome
• Accession: NZ_CP024785
• Organism: Nostoc flagelliforme CCNUN1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: COO91_RS07845
• Protein ID: WP_100898004.1
• Coordinates: 1713110..1713496 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2K8SKD2
• Locus tag: COO91_RS07840
• Protein ID: WP_069074142.1
• Coordinates: 1712859..1713107 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
COO91_RS07815	1708164..1709516	-	1353	WP_100897999.1	histidine phosphatase family protein	-
COO91_RS48870	1709950..1710213	+	264	WP_157816388.1	hypothetical protein	-
COO91_RS07820	1710633..1710986	-	354	WP_100898000.1	hypothetical protein	-
COO91_RS48875	1711287..1711568	-	282	WP_157816389.1	hypothetical protein	-
COO91_RS07825	1711534..1711968	-	435	WP_100898001.1	PIN domain-containing protein	-
COO91_RS07830	1711968..1712267	-	300	WP_100898002.1	hypothetical protein	-
COO91_RS07835	1712311..1712589	-	279	WP_100898003.1	type II toxin-antitoxin system ParD family antitoxin	-
COO91_RS07840	1712859..1713107	+	249	WP_069074142.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
COO91_RS07845	1713110..1713496	+	387	WP_100898004.1	type II toxin-antitoxin system VapC family toxin	Toxin
COO91_RS07850	1713747..1715720	-	1974	WP_100898005.1	tetratricopeptide repeat protein	-
COO91_RS07855	1715724..1716515	-	792	WP_100896900.1	IS5 family transposase	-
COO91_RS07865	1716591..1716887	-	297	WP_100898007.1	diversity-generating retroelement protein Avd	-
COO91_RS07870	1716999..1717862	-	864	WP_100898008.1	formylglycine-generating enzyme family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1715724..1716515	791

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-46)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14680.04 Da
• Isoelectric Point: 6.7246

>T88512 WP_100898004.1 NZ_CP024785:1713110-1713496 [Nostoc flagelliforme CCNUN1]
MRALLDTHAFLWWVTDDPQLSSTSRTIIADSGNILFLSVASVWEIVIKTKSGKLTLPEPVEEYIPNRLALNRFKSLDIQM
IHTLQIANLPNIHRDPFDRILIAQSQVENLPIVTIDQKITQYSVKTIW

Nucleotide

• Length: 387 bp

>T88512 NZ_CP024785:1713110-1713496 [Nostoc flagelliforme CCNUN1]
ATGAGAGCTTTACTGGATACCCATGCATTTCTTTGGTGGGTAACAGATGACCCTCAGTTATCTTCCACTAGTCGCACTAT
AATTGCTGACTCAGGTAATATTTTATTTCTGAGCGTGGCAAGTGTTTGGGAGATTGTCATCAAGACTAAATCGGGTAAGC
TAACTTTACCTGAACCTGTAGAAGAATATATTCCAAACCGACTAGCATTGAACCGCTTTAAGAGTCTAGATATTCAAATG
ATACACACTCTACAGATTGCCAATTTGCCAAACATCCACCGAGATCCGTTTGACCGGATTCTGATTGCCCAAAGTCAAGT
AGAGAATTTGCCAATTGTAACCATCGACCAAAAAATAACACAGTATTCTGTCAAGACTATCTGGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8761.08 Da
• Isoelectric Point: 3.9652

>AT88512 WP_069074142.1 NZ_CP024785:1712859-1713107 [Nostoc flagelliforme CCNUN1]
MSITVNVSEVTAKFSELLSQVLLGEEVVIAQKGIPVARLVALTDTASPRIPGLDKGKVIIAPDFDEPLPEDILNDFDSSN
LV

Nucleotide

• Length: 249 bp

>AT88512 NZ_CP024785:1712859-1713107 [Nostoc flagelliforme CCNUN1]
ATGAGTATCACCGTTAATGTTTCTGAAGTAACTGCCAAGTTTTCTGAATTGCTGAGTCAGGTATTACTTGGTGAAGAGGT
GGTGATTGCACAGAAGGGTATTCCAGTTGCACGCCTAGTAGCTCTCACAGATACAGCCTCACCTCGAATTCCAGGATTGG
ATAAAGGTAAAGTTATAATTGCACCAGATTTTGACGAGCCTTTACCAGAAGATATCCTAAATGATTTTGACAGTTCTAAT
CTAGTTTAG

Structures

Antitoxin

• AlphaFold DB: A0A2K8SKD2