Detailed information of TA system TA088505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2775429..2776012
• Replicon: chromosome
• Accession: NZ_CP024780
• Organism: Pectobacterium brasiliense strain BZA12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A7V8QAI8
• Locus tag: CTV95_RS12525
• Protein ID: WP_012822278.1
• Coordinates: 2775429..2775734 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CTV95_RS12530
• Protein ID: WP_100017665.1
• Coordinates: 2775722..2776012 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTV95_RS12510	2771845..2772804	+	960	WP_039279295.1	ABC transporter permease	-
CTV95_RS12515	2772797..2773663	+	867	WP_010285293.1	ABC transporter permease	-
CTV95_RS12520	2773660..2775369	+	1710	WP_100017664.1	ABC transporter ATP-binding protein	-
CTV95_RS12525	2775429..2775734	-	306	WP_012822278.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CTV95_RS12530	2775722..2776012	-	291	WP_100017665.1	ribbon-helix-helix protein, CopG family	Antitoxin
CTV95_RS12535	2776074..2776928	-	855	WP_039279287.1	helix-turn-helix domain-containing protein	-
CTV95_RS12540	2776953..2777792	-	840	WP_100017666.1	HTH-type transcriptional activator RhaS	-
CTV95_RS22455	2777867..2778031	-	165	WP_157765232.1	hypothetical protein	-
CTV95_RS12545	2778128..2779618	+	1491	WP_100017667.1	rhamnulokinase	-
CTV95_RS12550	2779615..2780877	+	1263	WP_100017668.1	L-rhamnose isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11634.48 Da
• Isoelectric Point: 9.4590

>T88505 WP_012822278.1 NZ_CP024780:c2775734-2775429 [Pectobacterium brasiliense]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LTDRVVILTVKHQKEAGYQNP

Nucleotide

• Length: 306 bp

>T88505 NZ_CP024780:c2775734-2775429 [Pectobacterium brasiliense]
ATGCCACAAGTGATTGTTTCAGAACGCGCAAGACGTGATTTGCAGCGTCTGCAGGATTTTCTAAAAAACAAAAATGCGCT
GGCTGCGAAAAAGGCGGCTGAAGTTTTGATTCGCGGCATTCGTCAGTTAGAAGCGCTGCCGAATATCGGGCGACCCGTTG
AACATCTCCCTCTTGAATATCAGGAACTGGTGATCGAATTCGGCAGCAGCGGGTACGTGATGCTTTACCGCCATGATGAA
CTGACTGACAGAGTGGTGATCCTGACCGTCAAGCATCAAAAAGAAGCCGGTTACCAAAACCCTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11128.22 Da
• Isoelectric Point: 4.7845

>AT88505 WP_100017665.1 NZ_CP024780:c2776012-2775722 [Pectobacterium brasiliense]
MADTPRQTTTLRIDQDIKERLKTLADDRHSSAHALMLEAITEYVEREEKRSQYRKEALAAWEEYQSTGEHITADETVTWL
ESWGSGHEQDAPVCHK

Nucleotide

• Length: 291 bp

>AT88505 NZ_CP024780:c2776012-2775722 [Pectobacterium brasiliense]
ATGGCTGACACGCCACGCCAAACCACGACGCTGCGCATCGATCAGGACATTAAAGAACGACTGAAAACGTTGGCCGATGA
CCGCCATAGCTCAGCCCATGCGCTAATGCTGGAAGCCATCACCGAATACGTGGAGCGTGAAGAAAAACGCAGTCAGTACC
GTAAAGAGGCGCTGGCCGCGTGGGAGGAATACCAGAGCACCGGCGAACACATCACCGCCGATGAGACGGTCACCTGGTTA
GAATCCTGGGGTTCTGGGCATGAACAGGATGCGCCTGTATGCCACAAGTGA

Structures

Toxin

• AlphaFold DB: A0A7V8QAI8