Detailed information of TA system TA088491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 2194932..2195439
• Replicon: chromosome
• Accession: NZ_CP024731
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 1262

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CTM64_RS11505
• Protein ID: WP_099986325.1
• Coordinates: 2195179..2195439 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: U7TRN8
• Locus tag: CTM64_RS11500
• Protein ID: WP_005892688.1
• Coordinates: 2194932..2195186 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM64_RS11465	2190003..2190392	+	390	WP_099986329.1	DUF5376 family protein	-
CTM64_RS11470	2190471..2190959	+	489	Protein_2165	hemolysin	-
CTM64_RS11480	2192373..2192924	+	552	WP_099986327.1	hypothetical protein	-
CTM64_RS11485	2193155..2193590	+	436	Protein_2167	hemolysin	-
CTM64_RS11490	2193564..2194007	+	444	WP_100022126.1	hypothetical protein	-
CTM64_RS11495	2194004..2194660	+	657	WP_099986326.1	hypothetical protein	-
CTM64_RS11500	2194932..2195186	+	255	WP_005892688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTM64_RS11505	2195179..2195439	+	261	WP_099986325.1	Txe/YoeB family addiction module toxin	Toxin
CTM64_RS11510	2195449..2195952	+	504	WP_008819943.1	GNAT family N-acetyltransferase	-
CTM64_RS11515	2195981..2196466	+	486	WP_099986324.1	GNAT family N-acetyltransferase	-
CTM64_RS11525	2196727..2197377	+	651	WP_005966059.1	endonuclease III	-
CTM64_RS11530	2197457..2198650	+	1194	WP_099986323.1	cysteine desulfurase NifS	-
CTM64_RS11535	2198723..2199109	+	387	WP_005966057.1	Fe-S cluster assembly scaffold protein NifU	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10328.91 Da
• Isoelectric Point: 9.6577

>T88491 WP_099986325.1 NZ_CP024731:2195179-2195439 [Fusobacterium pseudoperiodonticum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGALKGIGKPEVLKNESAYSRRIDEKNRLVYRIVDGFMWIIAC
KGHYEE

Nucleotide

• Length: 261 bp

>T88491 NZ_CP024731:2195179-2195439 [Fusobacterium pseudoperiodonticum]
ATGAATAATTTGGTATGGACGCATAAGGCTTGGCAAGATTACTTATATTGGCAAACTCAAGATAAAAAAACTTTGAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGCTTTAAAAGGAATAGGTAAGCCAGAAGTATTAAAAAACGAAA
GTGCATATAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGATGGCTTTATGTGGATAATTGCTTGT
AAAGGTCATTATGAGGAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9824.17 Da
• Isoelectric Point: 4.4453

>AT88491 WP_005892688.1 NZ_CP024731:2194932-2195186 [Fusobacterium pseudoperiodonticum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Nucleotide

• Length: 255 bp

>AT88491 NZ_CP024731:2194932-2195186 [Fusobacterium pseudoperiodonticum]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTTGATAATGATGAAGATAT
TATTATAACAAGAAAAAATGAGAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAGTTTTTAAAAGCTATGAGGA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAAGCAGGAAAAGGAGAAATTCATGATTTAATAGAG
GTTGATGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A806UAF3