Detailed information of TA system TA088490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 740996..741488
• Replicon: chromosome
• Accession: NZ_CP024731
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 1262

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CTM64_RS03840
• Protein ID: WP_099987789.1
• Coordinates: 740996..741262 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CTM64_RS03845
• Protein ID: WP_099987788.1
• Coordinates: 741270..741488 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM64_RS03820	737072..737350	+	279	WP_005966535.1	HU family DNA-binding protein	-
CTM64_RS03825	737437..738435	-	999	WP_099987792.1	cobalamin biosynthesis protein CobD	-
CTM64_RS03830	738438..739364	-	927	WP_099987791.1	DUF4299 family protein	-
CTM64_RS03835	739384..740874	-	1491	WP_099987790.1	cobyric acid synthase	-
CTM64_RS03840	740996..741262	-	267	WP_099987789.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CTM64_RS03845	741270..741488	-	219	WP_099987788.1	CopG family transcriptional regulator	Antitoxin
CTM64_RS03850	741648..742262	+	615	WP_099987787.1	DUF479 domain-containing protein	-
CTM64_RS03855	742364..743032	-	669	WP_161940324.1	GntR family transcriptional regulator	-
CTM64_RS03860	743128..744093	-	966	WP_099987785.1	phosphoglycerate dehydrogenase family protein	-
CTM64_RS03865	744108..745379	-	1272	WP_099987784.1	TRAP transporter large permease	-
CTM64_RS03870	745391..745867	-	477	WP_099987783.1	TRAP transporter small permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (3-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10296.11 Da
• Isoelectric Point: 10.1967

>T88490 WP_099987789.1 NZ_CP024731:c741262-740996 [Fusobacterium pseudoperiodonticum]
MKYNVEYSKTAMNTIKKLDSLTSKLIRTWIEKNLIDTENPRIKGKALTGDLKGLWRYRVGDYRILADIQDDKIVILILDI
GHRSKIYL

Nucleotide

• Length: 267 bp

>T88490 NZ_CP024731:c741262-740996 [Fusobacterium pseudoperiodonticum]
ATGAAATATAATGTGGAATATTCTAAAACTGCTATGAATACTATAAAGAAATTGGATAGTTTAACTTCAAAGTTAATAAG
AACTTGGATAGAGAAAAATTTAATTGATACAGAAAATCCTAGAATAAAAGGTAAAGCCTTAACAGGTGATTTAAAAGGAT
TGTGGCGTTATAGAGTAGGAGATTATAGGATATTAGCTGATATTCAAGATGATAAAATAGTTATCTTAATTTTGGATATA
GGACATAGAAGCAAAATATATTTATAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8494.66 Da
• Isoelectric Point: 4.8356

>AT88490 WP_099987788.1 NZ_CP024731:c741488-741270 [Fusobacterium pseudoperiodonticum]
MGTTATLRLDETEKAIIQNYASSKGMTMSEFMKKVVLDYIEDEYDLKIYKEYLKEKENSTLKTYSHKEVWGE

Nucleotide

• Length: 219 bp

>AT88490 NZ_CP024731:c741488-741270 [Fusobacterium pseudoperiodonticum]
ATGGGAACAACAGCAACATTAAGATTAGATGAAACAGAAAAAGCAATCATACAAAATTATGCAAGTAGTAAAGGAATGAC
TATGTCTGAATTTATGAAAAAAGTAGTTCTTGATTATATTGAAGATGAATATGATTTAAAAATTTATAAAGAATATTTAA
AAGAAAAAGAAAATAGTACTTTAAAGACTTATTCACATAAAGAAGTTTGGGGAGAATAG