Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4848277..4848896 Replicon chromosome
Accession NZ_CP024712
Organism Pseudomonas syringae pv. actinidiae strain MAFF212063

Toxin (Protein)


Gene name tad Uniprot ID A0A2G9L4Q9
Locus tag CT122_RS22690 Protein ID WP_004397564.1
Coordinates 4848594..4848896 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0K8LSV9
Locus tag CT122_RS22685 Protein ID WP_004397562.1
Coordinates 4848277..4848597 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CT122_RS22665 4843441..4844775 + 1335 WP_004397555.1 virulence factor family protein -
CT122_RS22670 4844870..4846765 - 1896 WP_004397556.1 potassium transporter Kup -
CT122_RS22680 4847087..4848175 + 1089 WP_004397558.1 catalase family protein -
CT122_RS22685 4848277..4848597 - 321 WP_004397562.1 helix-turn-helix domain-containing protein Antitoxin
CT122_RS22690 4848594..4848896 - 303 WP_004397564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CT122_RS22695 4849183..4850526 + 1344 WP_004397566.1 30S ribosomal protein S12 methylthiotransferase RimO -
CT122_RS22700 4850628..4851068 + 441 WP_004397568.1 GNAT family N-acetyltransferase -
CT122_RS22705 4851162..4851872 + 711 WP_004397570.1 rRNA pseudouridine synthase -
CT122_RS22710 4851954..4852415 + 462 WP_004397572.1 DUF1456 family protein -
CT122_RS22715 4852429..4853121 + 693 WP_004397574.1 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-89)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11152.69 Da        Isoelectric Point: 8.0629

>T88424 WP_004397564.1 NZ_CP024712:c4848896-4848594 [Pseudomonas syringae pv. actinidiae]
MPDEVQDVFGFALSLAQEGSKHSQAKPMKGFSGAGVLEVVEDYDSDTYRAVYSVKFDAMVYVLHCFQKKSTSGIKTAKHD
IELIKSRLKAVQAHVESNRR

Download         Length: 303 bp

>T88424 NZ_CP024712:c4848896-4848594 [Pseudomonas syringae pv. actinidiae]
ATGCCTGACGAGGTGCAGGATGTATTTGGATTCGCCCTGAGTCTCGCGCAGGAAGGCTCCAAACACTCTCAAGCCAAACC
GATGAAGGGTTTCTCCGGAGCAGGGGTGTTGGAGGTCGTTGAGGACTATGATAGTGACACCTATCGCGCTGTATATTCCG
TGAAATTCGATGCAATGGTCTACGTTCTGCACTGTTTTCAGAAAAAGTCGACCTCGGGCATTAAAACGGCAAAACATGAT
ATTGAATTGATCAAATCACGACTCAAAGCCGTACAAGCACATGTAGAGAGTAATAGACGATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11639.62 Da        Isoelectric Point: 10.2027

>AT88424 WP_004397562.1 NZ_CP024712:c4848597-4848277 [Pseudomonas syringae pv. actinidiae]
MIDIEEGSGNVYADLGRADANEMSIKAQLASKIGTIIKARHLTQLQAAEILAMPQPKVSEMLRGKFRGISEAKMMDCLSR
LGRDVQIVVKAAPRSRREGRVEVVFA

Download         Length: 321 bp

>AT88424 NZ_CP024712:c4848597-4848277 [Pseudomonas syringae pv. actinidiae]
ATGATTGATATCGAAGAAGGTAGCGGCAACGTTTACGCTGATCTTGGGCGAGCTGATGCGAACGAAATGTCAATCAAGGC
TCAATTAGCCTCAAAAATCGGCACAATCATCAAGGCTCGACACCTGACCCAGCTCCAGGCGGCTGAGATACTGGCAATGC
CTCAGCCAAAGGTTTCAGAGATGCTTAGGGGCAAGTTCAGAGGCATAAGCGAGGCCAAAATGATGGACTGCCTTTCGCGT
CTCGGACGTGACGTGCAGATTGTGGTCAAGGCAGCACCTCGTTCTCGGCGAGAGGGGCGAGTTGAAGTTGTATTTGCTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G9L4Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A0K8LSV9

References