Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 598169..598695 Replicon chromosome
Accession NZ_CP024711
Organism Dickeya solani strain IFB 0099

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag DSOL99_RS02835 Protein ID WP_022632051.1
Coordinates 598169..598474 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag DSOL99_RS02840 Protein ID WP_022632052.1
Coordinates 598477..598695 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSOL99_RS02815 593397..593794 + 398 Protein_537 DUF3577 domain-containing protein -
DSOL99_RS02820 593910..595181 + 1272 WP_022632048.1 hypothetical protein -
DSOL99_RS02825 595185..595751 + 567 WP_024103901.1 hypothetical protein -
DSOL99_RS02830 595739..597679 + 1941 WP_022632050.1 hypothetical protein -
DSOL99_RS02835 598169..598474 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
DSOL99_RS02840 598477..598695 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DSOL99_RS02845 598754..599497 - 744 WP_022632053.1 hypothetical protein -
DSOL99_RS02855 600400..600750 - 351 WP_013316250.1 hypothetical protein -
DSOL99_RS21750 600873..601061 + 189 WP_033111580.1 hypothetical protein -
DSOL99_RS02860 601201..602460 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
DSOL99_RS02870 602858..603433 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 592318..602637 10319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T88404 WP_022632051.1 NZ_CP024711:c598474-598169 [Dickeya solani]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T88404 NZ_CP024711:c598474-598169 [Dickeya solani]
ATGCAATTCATTGTTTATGAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAGAGTGATATCGTCGAGAC
ACCCAAGCGGCGCATGGTCATTCCGCTTATCGAAGCACACCACCTGTCTGAGAAAGTGAATAAGACGTTGTTCCCTAAGA
TCCGCATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTACCTGTTGAAGTCATGGGTGAAGTGATT
GCGGATCTTGGCGACTACGCGGATGAGATTAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT88404 WP_022632052.1 NZ_CP024711:c598695-598477 [Dickeya solani]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT88404 NZ_CP024711:c598695-598477 [Dickeya solani]
ATGAAACACCGCGTCAGTGTTACCGTAGACAAAGACAACTATCAGGTTCTGAGTGCTGCCGGAGTCAACATTTCTGGGCT
GGTGAACGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGGAGTGGAAGAAAGAAAACAGTGAGGGGATGGAGG
AAGTCGCCCGATTTATCGCGCAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References