Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3782434..3784274 Replicon chromosome
Accession NZ_CP024710
Organism Dickeya solani strain IFB0223

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8VX87
Locus tag CTB91_RS16830 Protein ID WP_022634631.1
Coordinates 3782928..3784274 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CTB91_RS16825 Protein ID WP_099048985.1
Coordinates 3782434..3782817 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTB91_RS16800 3777751..3778590 - 840 WP_022634625.1 MurR/RpiR family transcriptional regulator -
CTB91_RS16805 3778765..3780354 + 1590 WP_022634626.1 gamma-glutamyltransferase family protein -
CTB91_RS16810 3780399..3780596 + 198 WP_022634627.1 oxalurate catabolism protein HpxX -
CTB91_RS16815 3780593..3782005 + 1413 WP_022634628.1 AtzE family amidohydrolase -
CTB91_RS16820 3782002..3782382 + 381 WP_022634629.1 oxalurate catabolism protein HpxZ -
CTB91_RS16825 3782434..3782817 - 384 WP_099048985.1 helix-turn-helix domain-containing protein Antitoxin
CTB91_RS16830 3782928..3784274 - 1347 WP_022634631.1 type II toxin-antitoxin system HipA family toxin Toxin
CTB91_RS16835 3784547..3785494 - 948 WP_022634632.1 allantoinase PuuE -
CTB91_RS16840 3785538..3786275 - 738 WP_022634633.1 allantoin racemase -
CTB91_RS16845 3786272..3787015 - 744 WP_022634634.1 GntR family transcriptional regulator -
CTB91_RS16850 3787168..3788652 + 1485 WP_022634635.1 NCS1 family nucleobase:cation symporter-1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-104)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50541.28 Da        Isoelectric Point: 4.9663

>T88401 WP_022634631.1 NZ_CP024710:c3784274-3782928 [Dickeya solani]
MERLTVQAFIDNAWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Download         Length: 1347 bp

>T88401 NZ_CP024710:c3784274-3782928 [Dickeya solani]
ATGGAACGACTGACTGTACAGGCGTTTATCGATAATGCGTGGCAGGATATTGCCGAGATCGGTTTTCCCGAGAGCGACCA
GGATAATTACCTGCTGACCCGGCTGGATTATGCGTCCGATTATGGCCTTGACTATATGGATTGCGACGACCACCACGCGG
TTTCCGTCAATTACCCGGTTCGGATCTTCTTTGATGATGGCGGTGAGCTCGGATGGATGCGCTTTCTGGATGACATCATG
CCGGCGGGGGCCAGCCGAAAATATTGGGTTGACCACCTTGATCTCTCGGGGCTGCCGGCACCGTTGCAAAATTATGTCTT
GCTGCGGCATGCCACCATCGCACCGGTCGGTAATTTGCGCATCAAGGAGTCGATTCCTGTGCGGCATGAAGGTGCAACCC
GCTTTTTCAGCGTGGAGGATGTGAAGAACCGGGCTGCCGATTTTCTGGATTATGCGCAGCAGCGCGGTGCCGCTGCCGGG
GGCGCTACAGGGGCGGGCGGTGAGGCGCCAAAGCTGCTGTTGCGTTGTAATGCCGACGATCGGGTGTGGATCGATACCTG
GCAGGATAAGACCGACTGCCGCGATACCGCCTATCTGGTGAAGTTTCCGCGCGGGCAACGCAGTGAGATTGACTGCGACA
TCCTGCGGGCCGAGTTTCATTACTACCATGAATTAGCCGCGATGGGGTTCGACACCATTCCTGTGGCGGGCATGCGTCTG
GAAGAGGGGCGGCATTACCCGTCGCTCTGGTTGCCGCGTTTTGATATCGAATTCCCCGGCGATGGGCGCGTGAAGCGTTA
TGGCATGGAATCAGTTTATTCCCTGTTGCGGGCCGGGCCGGGCAGCGCGCTGCGGCACGATCAAACGATTCGGGCGGTGA
TCGCCAAAATAGCGTCCAGCCATACGGTCAGCGTCGAGGGAAAGCCATTCGACCAAGCGGCGTTCGTGATCGAGTGGGTG
CGCCGCGATGTGCTGAATATTGCCTTCGGCAACAGCGATAACCACGGCCGCAATACCGCGTTTCTCAAGGACGAACAGGG
GATTCGGCTGGCGCCGATTTACGACTTCGCGCCGATGAAGGCCGACCCGGCAGGCATTGCCAGAGCGACCAAATGGCCGG
AGCCGCTGGAAATCGGCGGTGATTATCAGTTTGAGTGGATCGCGGAGCAGTTGTCCGACATGCTCCCGCCGGCGCTGTTG
ATGGAGAGATTGCGCGAGACGGCGGTGCAACTGGTTGGACTGAAAGCGCGGCTTCAGGCGCGCGGTGTGCCCGAGTCGAT
CCTAACCATGCCTTCCATCGGGTTTGATTACCTTCCTGAAAAGCTACAGCGGTGGGGGTTGTTATGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13731.06 Da        Isoelectric Point: 10.8242

>AT88401 WP_099048985.1 NZ_CP024710:c3782817-3782434 [Dickeya solani]
MLRPPVIAVAETADIPKARASKNSRPLNASERQSAMQSIIRRMMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTL
SEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILATAPASR

Download         Length: 384 bp

>AT88401 NZ_CP024710:c3782817-3782434 [Dickeya solani]
ATGCTGCGTCCCCCGGTCATTGCCGTGGCGGAGACGGCGGATATTCCCAAAGCGAGAGCATCAAAAAATTCCAGACCACT
CAATGCCAGTGAGAGACAGTCTGCGATGCAAAGCATTATCCGCAGGATGATGGTCGGGGAGATATCGCAGGGAAACGCGC
TCAGGGAATTGCGTCTCAGCGTTCTGGGGCTCAAGCAGGATGCCTACGCCAGTCTGGTAGGCGTGTCGCGCAAGACCTTG
TCCGAAATCGAGAATGACAAAGGCAATTACACGGCGGATATCATCAACAAGGTCTTTAAACCCTTTGGTCTGAAGATGGG
ATTAATTCCGGTATCGCCTTCTTTGCTCGCCGAGATACTCGCCACCGCGCCAGCCTCTCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8VX87

Antitoxin

Source ID Structure

References