Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2713659..2714254 Replicon chromosome
Accession NZ_CP024710
Organism Dickeya solani strain IFB0223

Toxin (Protein)


Gene name doc Uniprot ID E0SEA8
Locus tag CTB91_RS12140 Protein ID WP_013318177.1
Coordinates 2713659..2714036 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2K8VUJ6
Locus tag CTB91_RS12145 Protein ID WP_022633800.1
Coordinates 2714033..2714254 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTB91_RS12120 2709325..2709591 + 267 WP_022633797.1 hypothetical protein -
CTB91_RS12125 2709823..2710005 + 183 WP_072142890.1 hypothetical protein -
CTB91_RS12130 2710087..2711853 - 1767 WP_022633798.1 ATP-binding protein -
CTB91_RS12135 2711843..2713021 - 1179 WP_022633799.1 hypothetical protein -
CTB91_RS12140 2713659..2714036 - 378 WP_013318177.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
CTB91_RS12145 2714033..2714254 - 222 WP_022633800.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CTB91_RS12150 2714395..2715543 - 1149 WP_022633801.1 L-threonine dehydrogenase -
CTB91_RS12155 2715825..2716385 + 561 WP_026594485.1 NUDIX domain-containing protein -
CTB91_RS12160 2716457..2717134 - 678 WP_022633803.1 respiratory nitrate reductase subunit gamma -
CTB91_RS12165 2717134..2717853 - 720 WP_022633804.1 nitrate reductase molybdenum cofactor assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14320.39 Da        Isoelectric Point: 4.9309

>T88400 WP_013318177.1 NZ_CP024710:c2714036-2713659 [Dickeya solani]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK

Download         Length: 378 bp

>T88400 NZ_CP024710:c2714036-2713659 [Dickeya solani]
ATGAAATGGGTGAGTGCGCAGGACGTCATTGACTTCCATGATCGTATTTTGCAGGTGTTGCCTGGTGTGGTGGGTATGGC
TGATCCGGGTCGGGCTGAGGAGTTGATTTATCGAGTACAAAACCGTCTTTATTATGAAGGTGTGACCGAACTGTTTGAGT
TGGCGGCGACGTATTGGGTAACTATTGCTCGTGGTCATATTTTTAATGATGGCAATAAACGCACTGCTTTTTTTGTTACC
ATGACATTTTTGCGCCGCAATGGCATATTGATTGTCGATAACGATAATTCGCTGGAAGAACTCACCATTAAGGCGGCAAC
CGGAGAATGCCTGGTGTCGGAACTCGCCGAACAATTAAGACAACGGGTGGAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8207.33 Da        Isoelectric Point: 7.2021

>AT88400 WP_022633800.1 NZ_CP024710:c2714254-2714033 [Dickeya solani]
MKTYTITEARQNIATVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTIKALADR

Download         Length: 222 bp

>AT88400 NZ_CP024710:c2714254-2714033 [Dickeya solani]
ATGAAGACTTATACCATTACTGAAGCCCGGCAAAATATTGCGACAGTCATTGATACGGCGGCCAGCGGTGAGCCGGTAGA
GATTAAGCGTCGGGATGGCACCTCGGCTGTACTCATCCCCAAAGCAGAGTTTGAGGCTTATCAGAAAGCCAGATTAGACG
CTGAATTCGATTTCATCATGCAGCGCCACGGACACACAATCAAAGCGCTCGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SEA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8VUJ6

References