Detailed information of TA system TA088390

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1879107..1879660
• Replicon: chromosome
• Accession: NZ_CP024710
• Organism: Dickeya solani strain IFB0223

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: CTB91_RS08460
• Protein ID: WP_022633101.1
• Coordinates: 1879346..1879660 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A2K8W593
• Locus tag: CTB91_RS08455
• Protein ID: WP_022633100.1
• Coordinates: 1879107..1879343 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTB91_RS08440	1874683..1876332	+	1650	WP_022633097.1	hypothetical protein	-
CTB91_RS08445	1876693..1877094	-	402	WP_023637748.1	hypothetical protein	-
CTB91_RS21845	1877158..1877451	-	294	WP_146053334.1	hypothetical protein	-
CTB91_RS08450	1877842..1878786	+	945	WP_022633099.1	DUF1738 domain-containing protein	-
CTB91_RS08455	1879107..1879343	+	237	WP_022633100.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
CTB91_RS08460	1879346..1879660	+	315	WP_022633101.1	CcdB family protein	Toxin
CTB91_RS08465	1879657..1879914	-	258	WP_022633102.1	hypothetical protein	-
CTB91_RS08470	1880090..1881397	-	1308	WP_022633103.1	type II toxin-antitoxin system HipA family toxin	-
CTB91_RS08475	1881397..1881804	-	408	WP_071598628.1	helix-turn-helix transcriptional regulator	-
CTB91_RS08485	1882187..1882933	-	747	WP_022633104.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hcp	1870124..1918502	48378

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11459.38 Da
• Isoelectric Point: 7.9859

>T88390 WP_022633101.1 NZ_CP024710:1879346-1879660 [Dickeya solani]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T88390 NZ_CP024710:1879346-1879660 [Dickeya solani]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGCTGTTTACCCGCTGTTGCTCGATGTCACAAGCGATATTATTGG
GCAGTTGAATCGCCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTATCCGGCAGGCCGCCGACCAGATCGTCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTGCAGGCACTGGGG
GCGGTGTTTTGTGATGCGTCTCAGTATCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATCGACGGCATTTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9020.06 Da
• Isoelectric Point: 6.2206

>AT88390 WP_022633100.1 NZ_CP024710:1879107-1879343 [Dickeya solani]
MTAKQRNTQSVTMTVERALLVRAREAGINLSAILTTALDAELRHHEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT88390 NZ_CP024710:1879107-1879343 [Dickeya solani]
ATGACCGCGAAACAACGCAACACGCAAAGCGTGACCATGACGGTGGAGCGTGCCTTACTGGTCCGGGCGCGTGAAGCGGG
CATTAACCTGAGTGCCATCCTGACAACCGCCCTGGATGCAGAGCTTCGCCACCATGAAGCAAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAATGGCTGTTTCAGTGATGAATACAGGACGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2K8W593