Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1764330..1764947 Replicon chromosome
Accession NZ_CP024710
Organism Dickeya solani strain IFB0223

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag CTB91_RS07955 Protein ID WP_012764944.1
Coordinates 1764768..1764947 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K8W4Y6
Locus tag CTB91_RS07950 Protein ID WP_022633005.1
Coordinates 1764330..1764740 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTB91_RS07925 1759830..1760747 + 918 WP_023637727.1 iron-siderophore ABC transporter substrate-binding protein -
CTB91_RS07930 1760744..1761766 + 1023 WP_022633001.1 iron ABC transporter permease -
CTB91_RS07935 1761759..1762808 + 1050 WP_022633002.1 iron ABC transporter permease -
CTB91_RS07940 1762820..1763665 + 846 WP_023637730.1 ABC transporter ATP-binding protein -
CTB91_RS07945 1763662..1764327 + 666 WP_022633004.1 RraA family protein -
CTB91_RS07950 1764330..1764740 - 411 WP_022633005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CTB91_RS07955 1764768..1764947 - 180 WP_012764944.1 type II toxin-antitoxin system HicA family toxin Toxin
CTB91_RS07960 1765269..1765631 + 363 WP_071598627.1 hypothetical protein -
CTB91_RS07970 1765967..1767022 - 1056 WP_022633006.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T88389 WP_012764944.1 NZ_CP024710:c1764947-1764768 [Dickeya solani]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T88389 NZ_CP024710:c1764947-1764768 [Dickeya solani]
ATGGACAGCAGGACGCTAATAGCAGAAATCAAGGCCGATGGATGGGAACTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCGGGATTAGTGACCATCCCACACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAAGCGGGAATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14499.48 Da        Isoelectric Point: 4.3391

>AT88389 WP_022633005.1 NZ_CP024710:c1764740-1764330 [Dickeya solani]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Download         Length: 411 bp

>AT88389 NZ_CP024710:c1764740-1764330 [Dickeya solani]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACTCATGCCTACGGCGTGACAGTGCCGGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAGGCCATCGCCAATGCCAAAGACGCGATCACCGGCCATATCGAGCTGCTGATCGAGA
TGGGTCAGGATATTCCTGCTGTGTCATCAGTCGGAACGCTGGCGAAAGCACCGGAGTACACCGGTTACACCTGGGCTGTT
GTTGATATCGATGTCACCCGGCTGATGGGTGGGGCAGAGAAAATTAATGTCACGTTGCCGAAATCGCTGATTGACCGTAT
TGACCGTTGCGTAGCGAGTAACCCGGAATTTAAGAGCCGCTCAGGGTTCCTTGCTCAGGCAGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4W9

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W4Y6

References