Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1219300..1219925 Replicon chromosome
Accession NZ_CP024710
Organism Dickeya solani strain IFB0223

Toxin (Protein)


Gene name Hha Uniprot ID A0A2K8W3K4
Locus tag CTB91_RS05670 Protein ID WP_022632574.1
Coordinates 1219300..1219503 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8W3I1
Locus tag CTB91_RS05675 Protein ID WP_022632575.1
Coordinates 1219557..1219925 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTB91_RS05640 1214940..1215278 + 339 WP_002208627.1 P-II family nitrogen regulator -
CTB91_RS05645 1215321..1216613 + 1293 WP_022632570.1 ammonium transporter AmtB -
CTB91_RS05650 1216709..1217572 - 864 WP_022632571.1 acyl-CoA thioesterase II -
CTB91_RS05655 1217824..1218381 + 558 WP_022632572.1 YbaY family lipoprotein -
CTB91_RS05660 1218410..1218739 - 330 WP_022632573.1 MGMT family protein -
CTB91_RS05670 1219300..1219503 - 204 WP_022632574.1 hemolysin expression modulator Hha Toxin
CTB91_RS05675 1219557..1219925 - 369 WP_022632575.1 Hha toxicity modulator TomB Antitoxin
CTB91_RS05680 1220433..1220576 - 144 WP_022632576.1 type B 50S ribosomal protein L36 -
CTB91_RS05685 1220592..1220843 - 252 WP_022632577.1 type B 50S ribosomal protein L31 -
CTB91_RS05690 1221020..1224166 - 3147 WP_022632578.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8161.52 Da        Isoelectric Point: 8.8580

>T88387 WP_022632574.1 NZ_CP024710:c1219503-1219300 [Dickeya solani]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T88387 NZ_CP024710:c1219503-1219300 [Dickeya solani]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGATCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAGATACGTTCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14223.06 Da        Isoelectric Point: 5.1663

>AT88387 WP_022632575.1 NZ_CP024710:c1219925-1219557 [Dickeya solani]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT88387 NZ_CP024710:c1219925-1219557 [Dickeya solani]
ATGGATGAGTACACACCCCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCATGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGCTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGCAATTACGGTATCAATGACACCGAGTTGCGGAAATGGCAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W3K4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W3I1

References