Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 595020..595546 Replicon chromosome
Accession NZ_CP024710
Organism Dickeya solani strain IFB0223

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag CTB91_RS02820 Protein ID WP_022632051.1
Coordinates 595020..595325 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag CTB91_RS02825 Protein ID WP_022632052.1
Coordinates 595328..595546 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTB91_RS02800 590242..590639 + 398 Protein_535 DUF3577 domain-containing protein -
CTB91_RS02805 590755..592026 + 1272 WP_022632048.1 hypothetical protein -
CTB91_RS02810 592030..592602 + 573 WP_022632049.1 hypothetical protein -
CTB91_RS02815 592590..594530 + 1941 WP_022632050.1 hypothetical protein -
CTB91_RS02820 595020..595325 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
CTB91_RS02825 595328..595546 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
CTB91_RS02830 595605..596348 - 744 WP_022632053.1 hypothetical protein -
CTB91_RS02840 597251..597601 - 351 WP_013316250.1 hypothetical protein -
CTB91_RS21785 597724..597912 + 189 WP_033111580.1 hypothetical protein -
CTB91_RS02845 598052..599311 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
CTB91_RS02855 599709..600284 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 589163..599488 10325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T88385 WP_022632051.1 NZ_CP024710:c595325-595020 [Dickeya solani]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T88385 NZ_CP024710:c595325-595020 [Dickeya solani]
ATGCAATTCATTGTTTATGAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAGAGTGATATCGTCGAGAC
ACCCAAGCGGCGCATGGTCATTCCGCTTATCGAAGCACACCACCTGTCTGAGAAAGTGAATAAGACGTTGTTCCCTAAGA
TCCGCATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTACCTGTTGAAGTCATGGGTGAAGTGATT
GCGGATCTTGGCGACTACGCGGATGAGATTAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT88385 WP_022632052.1 NZ_CP024710:c595546-595328 [Dickeya solani]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT88385 NZ_CP024710:c595546-595328 [Dickeya solani]
ATGAAACACCGCGTCAGTGTTACCGTAGACAAAGACAACTATCAGGTTCTGAGTGCTGCCGGAGTCAACATTTCTGGGCT
GGTGAACGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGGAGTGGAAGAAAGAAAACAGTGAGGGGATGGAGG
AAGTCGCCCGATTTATCGCGCAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References