Detailed information of TA system TA088384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 589406..590190
• Replicon: chromosome
• Accession: NZ_CP024710
• Organism: Dickeya solani strain IFB0223

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: CTB91_RS02795
• Protein ID: WP_022632047.1
• Coordinates: 589696..590190 (+)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A2K8W1V4
• Locus tag: CTB91_RS02790
• Protein ID: WP_022632046.1
• Coordinates: 589406..589699 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTB91_RS02770	585232..585684	+	453	WP_022632042.1	hypothetical protein	-
CTB91_RS02775	585727..586023	+	297	WP_022632043.1	hypothetical protein	-
CTB91_RS02780	586051..586758	+	708	WP_022632044.1	SDR family oxidoreductase	-
CTB91_RS02785	587750..589001	-	1252	Protein_532	tyrosine-type recombinase/integrase	-
CTB91_RS02790	589406..589699	+	294	WP_022632046.1	DUF1778 domain-containing protein	Antitoxin
CTB91_RS02795	589696..590190	+	495	WP_022632047.1	GNAT family N-acetyltransferase	Toxin
CTB91_RS02800	590242..590639	+	398	Protein_535	DUF3577 domain-containing protein	-
CTB91_RS02805	590755..592026	+	1272	WP_022632048.1	hypothetical protein	-
CTB91_RS02810	592030..592602	+	573	WP_022632049.1	hypothetical protein	-
CTB91_RS02815	592590..594530	+	1941	WP_022632050.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	589163..599488	10325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (66-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-95)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 17639.41 Da
• Isoelectric Point: 6.8524

>T88384 WP_022632047.1 NZ_CP024710:589696-590190 [Dickeya solani]
MISAPEPLHAEHVLSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDDSRVLAYYSLASSAVATTAAPGRFRRNMPDPI
PVVVLGRLAVDTSLHGQGVGRALVRDAGLRVIQVADTIGIRGMLVHALSDEARDFYLRVGFEPSPIDPMILMVTLGDLVG
SLSI

Nucleotide

• Length: 495 bp

>T88384 NZ_CP024710:589696-590190 [Dickeya solani]
ATGATCTCTGCTCCTGAGCCACTCCACGCCGAACATGTACTATCTTCATTCTGTTGCGGTGTGGAGTCTATGGACAACTG
GCTGAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCCCGAACTTTCGTCAGTTGCGATGATTCAAGAGTGTTGG
CGTATTACTCATTGGCTTCCAGCGCCGTGGCAACAACTGCCGCCCCCGGACGCTTTCGTCGCAATATGCCCGATCCGATC
CCGGTGGTAGTGCTGGGACGTCTGGCGGTTGATACGTCATTGCATGGTCAGGGCGTTGGCCGGGCGCTGGTGCGTGATGC
CGGGCTACGGGTGATTCAGGTAGCGGATACTATCGGCATTCGCGGGATGTTGGTTCATGCGCTGTCTGATGAAGCGCGTG
ATTTTTACCTACGAGTGGGGTTTGAACCTTCACCGATTGACCCGATGATTTTGATGGTAACGTTGGGGGATTTGGTGGGG
AGTTTATCAATTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10942.53 Da
• Isoelectric Point: 9.8078

>AT88384 WP_022632046.1 NZ_CP024710:589406-589699 [Dickeya solani]
MPVTNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPEPN
AALRKTMQTPAPWEQKK

Nucleotide

• Length: 294 bp

>AT88384 NZ_CP024710:589406-589699 [Dickeya solani]
ATGCCAGTGACGAACAGCGTTTCTGTTAAACGCGAAACATTGAATTTACGCATCAAGCCCGCCGAACGCGATCTGATCGA
TCGTGCAGCGAAGGCCAGAGGAAAAAATCGTACTGATTTTGTTCTTGAGGCTGCTCGCGCCGCCGCAGAGGAAGCGTTGA
TCGATCAGCGTATCATCATGGCAGATCCAGATGCCTATCAGGAATTCCTTGCTCGCTTGGATCAGGCTCCTGAGCCAAAT
GCCGCGCTGCGTAAAACCATGCAAACGCCTGCACCGTGGGAACAGAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2K8W1V4