Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 860365..861022 Replicon chromosome
Accession NZ_CP024707
Organism Klebsiella pneumoniae strain cr-hvkp3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CTM43_RS04335 Protein ID WP_002916310.1
Coordinates 860612..861022 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CTM43_RS04330 Protein ID WP_002916312.1
Coordinates 860365..860631 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTM43_RS04305 855573..857006 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
CTM43_RS04310 857125..857853 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CTM43_RS04315 857903..858214 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
CTM43_RS04320 858378..859037 + 660 WP_002916317.1 hemolysin III family protein -
CTM43_RS04325 859136..860119 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CTM43_RS04330 860365..860631 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CTM43_RS04335 860612..861022 + 411 WP_002916310.1 protein YgfX Toxin
CTM43_RS04340 861029..861550 - 522 WP_002916308.1 flavodoxin FldB -
CTM43_RS04345 861651..862547 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CTM43_RS04350 862570..863283 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CTM43_RS04355 863289..865022 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T88367 WP_002916310.1 NZ_CP024707:860612-861022 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T88367 NZ_CP024707:860612-861022 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT88367 WP_002916312.1 NZ_CP024707:860365-860631 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT88367 NZ_CP024707:860365-860631 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References