Detailed information of TA system TA088362

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-DinJ
• Location: 319948..320480
• Replicon: chromosome
• Accession: NZ_CP024705
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 2653

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CTN00_RS01590
• Protein ID: WP_005974572.1
• Coordinates: 319948..320214 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CTN00_RS01595
• Protein ID: WP_099989058.1
• Coordinates: 320214..320480 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTN00_RS01570	316253..317104	-	852	WP_099996415.1	DNA-processing protein DprA	-
CTN00_RS01575	317129..317929	-	801	WP_099990593.1	tetratricopeptide repeat protein	-
CTN00_RS01580	317910..319124	-	1215	WP_099996416.1	exodeoxyribonuclease VII large subunit	-
CTN00_RS01585	319352..319576	+	225	WP_099971989.1	hypothetical protein	-
CTN00_RS01590	319948..320214	-	267	WP_005974572.1	Txe/YoeB family addiction module toxin	Toxin
CTN00_RS01595	320214..320480	-	267	WP_099989058.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CTN00_RS01600	320793..321860	-	1068	WP_099996417.1	site-specific integrase	-
CTN00_RS01605	321895..322086	-	192	WP_099996418.1	hypothetical protein	-
CTN00_RS01610	322155..322400	-	246	WP_099996419.1	hypothetical protein	-
CTN00_RS01615	322419..323135	-	717	WP_099996420.1	ORF6C domain-containing protein	-
CTN00_RS01620	323148..323438	-	291	WP_099996421.1	hypothetical protein	-
CTN00_RS11385	323551..323727	-	177	WP_147384118.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
CTN00_RS11440	323861..324028	-	168	WP_153232600.1	hypothetical protein	-
CTN00_RS01625	324044..324619	-	576	WP_099996422.1	hypothetical protein	-
CTN00_RS11445	324616..324774	-	159	WP_194250149.1	hypothetical protein	-
CTN00_RS01630	324829..325029	-	201	WP_099996423.1	hypothetical protein	-
CTN00_RS11450	325046..325201	-	156	WP_153232602.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	313929..372230	58301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10383.91 Da
• Isoelectric Point: 9.3517

>T88362 WP_005974572.1 NZ_CP024705:c320214-319948 [Fusobacterium pseudoperiodonticum]
MKISFSIQAWEEYLYFQTQDKKTLKKINELIKDIERNGALNGIGKPEKLTNNLTGLYSRRINDKDRLVYKIENDFIVILQ
CKGHYSDN

Nucleotide

• Length: 267 bp

>T88362 NZ_CP024705:c320214-319948 [Fusobacterium pseudoperiodonticum]
ATGAAAATTAGTTTTTCTATTCAAGCCTGGGAAGAATATTTATATTTCCAAACTCAAGATAAGAAAACATTGAAGAAAAT
AAATGAACTTATAAAAGATATTGAAAGAAATGGAGCATTGAATGGAATAGGTAAACCTGAAAAACTAACCAATAATTTAA
CAGGATTGTATAGTAGGAGAATCAATGACAAAGATAGATTAGTCTATAAAATAGAAAATGATTTTATAGTTATATTACAG
TGTAAAGGACATTATAGTGATAATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10158.86 Da
• Isoelectric Point: 4.5609

>AT88362 WP_099989058.1 NZ_CP024705:c320480-320214 [Fusobacterium pseudoperiodonticum]
MSMKLVNIRMDEDLKKEMEIVCNDLGINITTAFTIFAKKLTREKRIPFSVSIDPFYSDENIKALENSINEVKDGKVIMKT
IEELEAME

Nucleotide

• Length: 267 bp

>AT88362 NZ_CP024705:c320480-320214 [Fusobacterium pseudoperiodonticum]
ATGTCAATGAAATTAGTAAATATAAGAATGGACGAAGATTTGAAAAAAGAGATGGAAATTGTTTGTAATGATTTAGGAAT
TAATATAACAACCGCATTTACTATATTTGCAAAAAAATTAACAAGAGAAAAAAGAATTCCTTTTAGTGTTTCAATAGATC
CATTTTATTCAGATGAAAATATAAAAGCTTTAGAAAATTCAATTAATGAAGTAAAAGATGGTAAAGTTATTATGAAAACT
ATTGAAGAATTGGAGGCTATGGAATAA