Detailed information of TA system TA088361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 171255..171732
• Replicon: chromosome
• Accession: NZ_CP024704
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 2555

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CTM98_RS00905
• Protein ID: WP_100025733.1
• Coordinates: 171255..171485 (-)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: U7TRN8
• Locus tag: CTM98_RS00910
• Protein ID: WP_005892688.1
• Coordinates: 171478..171732 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM98_RS00875	167251..167901	-	651	WP_005966059.1	endonuclease III	-
CTM98_RS00880	168203..168688	-	486	WP_100025728.1	GNAT family N-acetyltransferase	-
CTM98_RS00885	168717..169220	-	504	WP_147386747.1	GNAT family N-acetyltransferase	-
CTM98_RS00890	169363..170607	-	1245	WP_100025730.1	transposase	-
CTM98_RS00895	170876..171061	-	186	WP_100025731.1	hypothetical protein	-
CTM98_RS00905	171255..171485	-	231	WP_100025733.1	Txe/YoeB family addiction module toxin	Toxin
CTM98_RS00910	171478..171732	-	255	WP_005892688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTM98_RS00915	172074..173183	-	1110	WP_100025734.1	hypothetical protein	-
CTM98_RS00920	173487..173996	-	510	WP_100025735.1	hypothetical protein	-
CTM98_RS00935	174851..175255	-	405	WP_100025737.1	hypothetical protein	-
CTM98_RS00940	175236..175460	-	225	WP_100025738.1	hypothetical protein	-
CTM98_RS00945	175688..176326	-	639	WP_100025739.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-75)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 9080.51 Da
• Isoelectric Point: 10.2498

>T88361 WP_100025733.1 NZ_CP024704:c171485-171255 [Fusobacterium pseudoperiodonticum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGALKGIGKPEVLKNESAYSRRIDEKNRLVYKIVDGFIK

Nucleotide

• Length: 231 bp

>T88361 NZ_CP024704:c171485-171255 [Fusobacterium pseudoperiodonticum]
ATGAATAATTTAGTATGGACGCATAAGGCTTGGCAAGATTACTTATATTGGCAAACTCAAGATAAAAAAACTTTGAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGCTTTAAAAGGAATAGGCAAGCCAGAAGTATTAAAAAATGAAA
GTGCATACAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAAAATTGTAGATGGCTTTATTAAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9824.17 Da
• Isoelectric Point: 4.4453

>AT88361 WP_005892688.1 NZ_CP024704:c171732-171478 [Fusobacterium pseudoperiodonticum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Nucleotide

• Length: 255 bp

>AT88361 NZ_CP024704:c171732-171478 [Fusobacterium pseudoperiodonticum]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTTGATAATGATGAAGATAT
TATTATAACAAGAAAAAATGAGAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAGTTTTTAAAAGCTATGAGGA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAAGCAGGAAAAGGAGAAATTCATGATTTAATAGAG
GTTGATGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A806UAF3