Detailed information of TA system TA088360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 1434682..1435159
• Replicon: chromosome
• Accession: NZ_CP024703
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 2305

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CTM92_RS07210
• Protein ID: WP_099985459.1
• Coordinates: 1434929..1435159 (+)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: U7TRN8
• Locus tag: CTM92_RS07205
• Protein ID: WP_005892688.1
• Coordinates: 1434682..1434936 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM92_RS07185	1430822..1431373	+	552	WP_099993101.1	hypothetical protein	-
CTM92_RS07190	1431601..1432587	+	987	Protein_1357	hemolysin	-
CTM92_RS07195	1433422..1433802	+	381	WP_099993103.1	hypothetical protein	-
CTM92_RS07200	1433819..1434250	+	432	WP_099985460.1	hypothetical protein	-
CTM92_RS07205	1434682..1434936	+	255	WP_005892688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTM92_RS07210	1434929..1435159	+	231	WP_099985459.1	Txe/YoeB family addiction module toxin	Toxin
CTM92_RS07220	1435789..1437033	+	1245	WP_099993107.1	transposase	-
CTM92_RS07225	1437177..1437680	+	504	WP_099993109.1	GNAT family N-acetyltransferase	-
CTM92_RS07230	1437709..1438194	+	486	WP_099993111.1	GNAT family N-acetyltransferase	-
CTM92_RS07235	1438435..1439085	+	651	WP_005966059.1	endonuclease III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-72)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 9136.58 Da
• Isoelectric Point: 10.2817

>T88360 WP_099985459.1 NZ_CP024703:1434929-1435159 [Fusobacterium pseudoperiodonticum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGVLKGIGKPEVLKNESAYSRRIDEKNRLVYRIVDGFIK

Nucleotide

• Length: 231 bp

>T88360 NZ_CP024703:1434929-1435159 [Fusobacterium pseudoperiodonticum]
ATGAATAATTTGGTATGGACACATAAGGCTTGGCAAGATTACTTATATTGGCAAACTCAGGATAAAAAAACTTTGAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGTTTTAAAAGGAATAGGCAAGCCAGAAGTGTTAAAAAATGAAA
GTGCATACAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGATGGCTTTATTAAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9824.17 Da
• Isoelectric Point: 4.4453

>AT88360 WP_005892688.1 NZ_CP024703:1434682-1434936 [Fusobacterium pseudoperiodonticum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Nucleotide

• Length: 255 bp

>AT88360 NZ_CP024703:1434682-1434936 [Fusobacterium pseudoperiodonticum]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTTGATAACGATGAAGATAT
TATTATAACAAGAAAAAATGAGAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAATTTTTAAAAGCTATGAGAA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAAGCAGGAAAAGGAGAAATTCATGATTTAATAGAG
GTTGATGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A806UAF3