Detailed information of TA system TA088357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-DinJ
• Location: 1025716..1026248
• Replicon: chromosome
• Accession: NZ_CP024702
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 1282

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CTM86_RS05055
• Protein ID: WP_005974572.1
• Coordinates: 1025716..1025982 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4CX36
• Locus tag: CTM86_RS05060
• Protein ID: WP_005974575.1
• Coordinates: 1025982..1026248 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM86_RS05035	1021969..1022820	-	852	WP_099990592.1	DNA-processing protein DprA	-
CTM86_RS05040	1022845..1023645	-	801	WP_099990593.1	tetratricopeptide repeat protein	-
CTM86_RS05045	1023626..1024840	-	1215	WP_099990594.1	exodeoxyribonuclease VII large subunit	-
CTM86_RS05050	1025070..1025312	+	243	WP_099990595.1	hypothetical protein	-
CTM86_RS05055	1025716..1025982	-	267	WP_005974572.1	Txe/YoeB family addiction module toxin	Toxin
CTM86_RS05060	1025982..1026248	-	267	WP_005974575.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CTM86_RS05065	1026775..1027386	-	612	WP_099990596.1	Type 1 glutamine amidotransferase-like domain-containing protein	-
CTM86_RS05070	1027419..1028312	-	894	WP_099990597.1	hypothetical protein	-
CTM86_RS05075	1028329..1029120	-	792	WP_147387996.1	nickel/cobalt transporter	-
CTM86_RS05080	1029364..1029918	-	555	WP_099990598.1	DUF1007 family protein	-
CTM86_RS05085	1030113..1031054	+	942	WP_005968894.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-78)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10383.91 Da
• Isoelectric Point: 9.3517

>T88357 WP_005974572.1 NZ_CP024702:c1025982-1025716 [Fusobacterium pseudoperiodonticum]
MKISFSIQAWEEYLYFQTQDKKTLKKINELIKDIERNGALNGIGKPEKLTNNLTGLYSRRINDKDRLVYKIENDFIVILQ
CKGHYSDN

Nucleotide

• Length: 267 bp

>T88357 NZ_CP024702:c1025982-1025716 [Fusobacterium pseudoperiodonticum]
ATGAAAATTAGTTTTTCTATTCAAGCCTGGGAAGAATATTTATATTTTCAAACTCAAGATAAGAAAACATTGAAGAAAAT
AAATGAACTTATAAAAGATATTGAAAGAAACGGAGCATTGAATGGAATAGGTAAACCTGAAAAACTAACCAATAATTTAA
CAGGATTATATAGTAGGAGAATCAATGACAAAGATAGATTAGTCTATAAAATAGAAAATGATTTTATAGTTATATTACAG
TGTAAAGGACATTATAGTGATAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10157.88 Da
• Isoelectric Point: 4.6935

>AT88357 WP_005974575.1 NZ_CP024702:c1026248-1025982 [Fusobacterium pseudoperiodonticum]
MSMKLVNIRMDEDLKKEMEIVCNDLGINITTAFTIFAKKLTREKRIPFSVSIDPFYSNENIKALENSINEVKDGKVIMKT
IEELEAME

Nucleotide

• Length: 267 bp

>AT88357 NZ_CP024702:c1026248-1025982 [Fusobacterium pseudoperiodonticum]
ATGTCAATGAAATTAGTAAATATAAGAATGGATGAAGATTTGAAAAAAGAGATGGAAATTGTTTGTAATGATTTAGGTAT
TAATATAACAACTGCATTTACTATATTTGCAAAAAAATTAACAAGAGAAAAAAGAATTCCTTTTAGTGTCTCAATAGATC
CATTTTATTCAAATGAAAATATAAAAGCTTTAGAAAATTCAATTAATGAAGTAAAAGATGGTAAAGTTATTATGAAAACT
ATTGAAGAATTGGAGGCTATGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2G9E9N1