Detailed information of TA system TA088356

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2095655..2096192
• Replicon: chromosome
• Accession: NZ_CP024701
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 1277

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CTM78_RS10730
• Protein ID: WP_099989770.1
• Coordinates: 2095655..2095927 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K1GRY6
• Locus tag: CTM78_RS10735
• Protein ID: WP_005966269.1
• Coordinates: 2095929..2096192 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM78_RS10705	2091512..2091967	-	456	WP_099971679.1	SoxR reducing system RseC family protein	-
CTM78_RS10710	2092168..2092641	+	474	WP_099989764.1	hypothetical protein	-
CTM78_RS10715	2092698..2093693	-	996	WP_099989766.1	NAD-dependent epimerase/dehydratase family protein	-
CTM78_RS10720	2093841..2094908	-	1068	WP_099989767.1	PD-(D/E)XK nuclease family protein	-
CTM78_RS10725	2095099..2095602	+	504	WP_099989769.1	YfbM family protein	-
CTM78_RS10730	2095655..2095927	-	273	WP_099989770.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CTM78_RS10735	2095929..2096192	-	264	WP_005966269.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CTM78_RS10740	2096328..2096837	-	510	WP_099989772.1	transcription repressor NadR	-
CTM78_RS10745	2096830..2097690	-	861	WP_099989773.1	carboxylating nicotinate-nucleotide diphosphorylase	-
CTM78_RS10750	2097668..2098960	-	1293	WP_099989774.1	L-aspartate oxidase	-
CTM78_RS10755	2098962..2099858	-	897	WP_099989775.1	quinolinate synthase NadA	-
CTM78_RS10765	2100271..2100882	-	612	WP_099985564.1	LysE family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10724.50 Da
• Isoelectric Point: 9.2666

>T88356 WP_099989770.1 NZ_CP024701:c2095927-2095655 [Fusobacterium pseudoperiodonticum]
MYEIKTTTRFEKDLKLIKKRGYDIKLLKEVIDILSKGEKLEEKYKDHYLQGNYSGFKECHIKPDWLLIYKINDNVLVLTL
SRTGTHSDLF

Nucleotide

• Length: 273 bp

>T88356 NZ_CP024701:c2095927-2095655 [Fusobacterium pseudoperiodonticum]
ATGTATGAAATTAAAACCACAACTAGATTTGAAAAAGATTTAAAATTAATAAAAAAAAGAGGATATGATATAAAATTATT
AAAAGAAGTAATTGATATCTTATCTAAAGGAGAAAAATTAGAAGAAAAATATAAAGATCATTATTTACAGGGAAATTATT
CAGGATTTAAAGAGTGTCACATAAAACCTGATTGGTTACTAATTTATAAGATTAATGATAATGTACTTGTATTAACACTT
TCAAGAACAGGGACACACTCAGATTTATTTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9860.41 Da
• Isoelectric Point: 4.5348

>AT88356 WP_005966269.1 NZ_CP024701:c2096192-2095929 [Fusobacterium pseudoperiodonticum]
MAVINIRVNDEVKKEAETIFKALGLNMSVAMNLFLKKCINENGIPFDLKVPNKETIEAMEETNKILNGDIERKSYKNADE
LFEDLGV

Nucleotide

• Length: 264 bp

>AT88356 NZ_CP024701:c2096192-2095929 [Fusobacterium pseudoperiodonticum]
ATGGCTGTTATAAATATTCGTGTTAATGATGAAGTAAAGAAAGAGGCTGAAACTATTTTTAAGGCTTTAGGTCTTAATAT
GTCAGTTGCAATGAATTTATTTTTAAAAAAATGTATAAATGAAAATGGAATTCCATTTGATTTAAAGGTTCCAAATAAAG
AAACAATAGAAGCAATGGAAGAGACTAATAAGATATTAAATGGAGATATAGAAAGAAAATCATATAAAAATGCTGATGAG
TTATTTGAAGATTTAGGTGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2D3NZ60