Detailed information of TA system TA088353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 156917..157424
• Replicon: chromosome
• Accession: NZ_CP024700
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 1263

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CTM74_RS00830
• Protein ID: WP_099986325.1
• Coordinates: 156917..157177 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: U7TRN8
• Locus tag: CTM74_RS00835
• Protein ID: WP_005892688.1
• Coordinates: 157170..157424 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM74_RS00800	153247..153633	-	387	WP_005966057.1	Fe-S cluster assembly scaffold protein NifU	-
CTM74_RS00805	153706..154899	-	1194	WP_099986323.1	cysteine desulfurase NifS	-
CTM74_RS00810	154979..155629	-	651	WP_005966059.1	endonuclease III	-
CTM74_RS00820	155890..156375	-	486	WP_099986324.1	GNAT family N-acetyltransferase	-
CTM74_RS00825	156404..156907	-	504	WP_008819943.1	GNAT family N-acetyltransferase	-
CTM74_RS00830	156917..157177	-	261	WP_099986325.1	Txe/YoeB family addiction module toxin	Toxin
CTM74_RS00835	157170..157424	-	255	WP_005892688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTM74_RS00840	157696..158352	-	657	WP_099986326.1	hypothetical protein	-
CTM74_RS14215	158349..158792	-	444	WP_100022126.1	hypothetical protein	-
CTM74_RS00845	158809..159363	-	555	WP_208617264.1	hypothetical protein	-
CTM74_RS00850	159432..159983	-	552	WP_099986327.1	hypothetical protein	-
CTM74_RS00860	161397..161885	-	489	Protein_141	hemolysin	-
CTM74_RS00865	161964..162353	-	390	WP_099986329.1	DUF5376 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10328.91 Da
• Isoelectric Point: 9.6577

>T88353 WP_099986325.1 NZ_CP024700:c157177-156917 [Fusobacterium pseudoperiodonticum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGALKGIGKPEVLKNESAYSRRIDEKNRLVYRIVDGFMWIIAC
KGHYEE

Nucleotide

• Length: 261 bp

>T88353 NZ_CP024700:c157177-156917 [Fusobacterium pseudoperiodonticum]
ATGAATAATTTGGTATGGACGCATAAGGCTTGGCAAGATTACTTATATTGGCAAACTCAAGATAAAAAAACTTTGAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGCTTTAAAAGGAATAGGTAAGCCAGAAGTATTAAAAAACGAAA
GTGCATATAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGATGGCTTTATGTGGATAATTGCTTGT
AAAGGTCATTATGAGGAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9824.17 Da
• Isoelectric Point: 4.4453

>AT88353 WP_005892688.1 NZ_CP024700:c157424-157170 [Fusobacterium pseudoperiodonticum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Nucleotide

• Length: 255 bp

>AT88353 NZ_CP024700:c157424-157170 [Fusobacterium pseudoperiodonticum]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTTGATAATGATGAAGATAT
TATTATAACAAGAAAAAATGAGAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAGTTTTTAAAAGCTATGAGGA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAAGCAGGAAAAGGAGAAATTCATGATTTAATAGAG
GTTGATGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A806UAF3