Detailed information of TA system TA088352

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 1279632..1280109
• Replicon: chromosome
• Accession: NZ_CP024699
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 1261

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CTM72_RS06335
• Protein ID: WP_100024846.1
• Coordinates: 1279632..1279862 (-)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: U7TRN8
• Locus tag: CTM72_RS06340
• Protein ID: WP_005892688.1
• Coordinates: 1279855..1280109 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM72_RS06310	1274842..1276035	-	1194	WP_100024841.1	cysteine desulfurase NifS	-
CTM72_RS06315	1276115..1276765	-	651	WP_100024842.1	endonuclease III	-
CTM72_RS06320	1277006..1277491	-	486	WP_100024843.1	GNAT family N-acetyltransferase	-
CTM72_RS06325	1277725..1278969	-	1245	WP_100024844.1	transposase	-
CTM72_RS06335	1279632..1279862	-	231	WP_100024846.1	Txe/YoeB family addiction module toxin	Toxin
CTM72_RS06340	1279855..1280109	-	255	WP_005892688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTM72_RS06345	1280283..1281194	-	912	WP_100024847.1	immunity 49 family protein	-
CTM72_RS06350	1281402..1281704	-	303	WP_100024848.1	hypothetical protein	-
CTM72_RS06355	1281817..1283214	-	1398	WP_100024849.1	ankyrin repeat domain-containing protein	-
CTM72_RS06360	1283244..1283429	-	186	Protein_1221	hypothetical protein	-
CTM72_RS06370	1284213..1284617	-	405	WP_100024851.1	hypothetical protein	-
CTM72_RS11765	1284598..1284750	-	153	WP_153232625.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-73)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 9150.61 Da
• Isoelectric Point: 10.2817

>T88352 WP_100024846.1 NZ_CP024699:c1279862-1279632 [Fusobacterium pseudoperiodonticum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELIKDIERNGVLKGIGKPEVLKNESAYSRRIDEKNRLVYRIVDGFIK

Nucleotide

• Length: 231 bp

>T88352 NZ_CP024699:c1279862-1279632 [Fusobacterium pseudoperiodonticum]
ATGAATAATTTGGTATGGACGCATAAGGCTTGGCAAGATTACTTATATTGGCAAACTCAGGATAAAAAAACTTTGAAAAA
GATAAATGAATTAATCAAAGATATTGAAAGAAATGGAGTTTTAAAAGGAATAGGCAAGCCAGAAGTATTAAAAAACGAAA
GTGCATACAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGATGGTTTTATTAAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9824.17 Da
• Isoelectric Point: 4.4453

>AT88352 WP_005892688.1 NZ_CP024699:c1280109-1279855 [Fusobacterium pseudoperiodonticum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Nucleotide

• Length: 255 bp

>AT88352 NZ_CP024699:c1280109-1279855 [Fusobacterium pseudoperiodonticum]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTTGATAACGATGAAGATAT
TATTATAACAAGAAAAAATGAGAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAGTTTTTAAAAGCTATGAGGA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAAGCAGGAAAAGGAGAAATTCATGATTTAATAGAG
GTTGATGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A806UAF3