Detailed information of TA system TA088350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-DinJ
• Location: 1980039..1980571
• Replicon: chromosome
• Accession: NZ_CP024698
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 1283

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CTM68_RS09945
• Protein ID: WP_099971988.1
• Coordinates: 1980305..1980571 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4CX36
• Locus tag: CTM68_RS09940
• Protein ID: WP_005974575.1
• Coordinates: 1980039..1980305 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM68_RS09915	1975121..1976086	-	966	WP_099971985.1	glutamate formimidoyltransferase	-
CTM68_RS09920	1976370..1976924	+	555	WP_099986048.1	DUF1007 family protein	-
CTM68_RS09925	1977168..1977959	+	792	WP_147384657.1	nickel/cobalt transporter	-
CTM68_RS09930	1977976..1978869	+	894	WP_099986049.1	hypothetical protein	-
CTM68_RS09935	1978901..1979512	+	612	WP_099971987.1	Type 1 glutamine amidotransferase-like domain-containing protein	-
CTM68_RS09940	1980039..1980305	+	267	WP_005974575.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CTM68_RS09945	1980305..1980571	+	267	WP_099971988.1	Txe/YoeB family addiction module toxin	Toxin
CTM68_RS09950	1980619..1980843	-	225	WP_099971989.1	hypothetical protein	-
CTM68_RS09955	1981071..1982285	+	1215	WP_099971990.1	exodeoxyribonuclease VII large subunit	-
CTM68_RS09960	1982266..1983066	+	801	WP_099971991.1	tetratricopeptide repeat protein	-
CTM68_RS09965	1983091..1983942	+	852	WP_099971992.1	DNA-processing protein DprA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-78)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10400.90 Da
• Isoelectric Point: 8.7937

>T88350 WP_099971988.1 NZ_CP024698:1980305-1980571 [Fusobacterium pseudoperiodonticum]
MKISFSIQAWEEYLYFQTQDKKTLKKINELIKDIERNGALNGIGKPEKLTNNLTGLYSRRINDKDRLVYKLEDDYIVILQ
CKGHYSDN

Nucleotide

• Length: 267 bp

>T88350 NZ_CP024698:1980305-1980571 [Fusobacterium pseudoperiodonticum]
ATGAAAATTAGTTTTTCTATTCAAGCCTGGGAAGAATATTTATATTTTCAAACTCAAGATAAGAAAACATTGAAGAAAAT
AAATGAACTTATAAAAGATATTGAAAGAAATGGAGCATTGAATGGAATAGGTAAACCTGAAAAACTAACCAATAATTTAA
CAGGATTGTATAGTAGGAGAATCAATGACAAAGATAGATTAGTCTATAAATTAGAAGATGATTATATAGTTATCCTACAA
TGTAAAGGACATTATAGTGATAATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10157.88 Da
• Isoelectric Point: 4.6935

>AT88350 WP_005974575.1 NZ_CP024698:1980039-1980305 [Fusobacterium pseudoperiodonticum]
MSMKLVNIRMDEDLKKEMEIVCNDLGINITTAFTIFAKKLTREKRIPFSVSIDPFYSNENIKALENSINEVKDGKVIMKT
IEELEAME

Nucleotide

• Length: 267 bp

>AT88350 NZ_CP024698:1980039-1980305 [Fusobacterium pseudoperiodonticum]
ATGTCAATGAAATTAGTAAATATAAGAATGGATGAAGATTTGAAAAAAGAGATGGAAATTGTTTGTAATGATTTAGGTAT
TAATATAACAACTGCATTTACTATATTTGCAAAAAAATTAACAAGAGAAAAAAGAATTCCTTTTAGTGTCTCAATAGATC
CATTTTATTCAAATGAAAATATAAAAGCTTTAGAAAATTCAATTAATGAAGTAAAAGATGGTAAAGTTATTATGAAAACT
ATTGAAGAATTGGAGGCTATGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2G9E9N1