Detailed information of TA system TA088349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 871277..871754
• Replicon: chromosome
• Accession: NZ_CP024698
• Organism: Fusobacterium pseudoperiodonticum strain KCOM 1283

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CTM68_RS04485
• Protein ID: WP_099985459.1
• Coordinates: 871277..871507 (-)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: U7TRN8
• Locus tag: CTM68_RS04490
• Protein ID: WP_005892688.1
• Coordinates: 871500..871754 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTM68_RS04455	867370..868020	-	651	WP_099985455.1	endonuclease III	-
CTM68_RS04460	868261..868746	-	486	WP_099985456.1	GNAT family N-acetyltransferase	-
CTM68_RS04465	868775..869278	-	504	WP_099985457.1	GNAT family N-acetyltransferase	-
CTM68_RS04470	869421..870665	-	1245	WP_099985458.1	transposase	-
CTM68_RS04485	871277..871507	-	231	WP_099985459.1	Txe/YoeB family addiction module toxin	Toxin
CTM68_RS04490	871500..871754	-	255	WP_005892688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTM68_RS04495	872186..872617	-	432	WP_099985460.1	hypothetical protein	-
CTM68_RS04500	872634..873014	-	381	WP_099985461.1	hypothetical protein	-
CTM68_RS04505	873021..873677	-	657	WP_099985462.1	hypothetical protein	-
CTM68_RS04510	873700..874134	-	435	WP_099985463.1	hypothetical protein	-
CTM68_RS04515	874160..874966	-	807	WP_099986166.1	hypothetical protein	-
CTM68_RS04520	875255..875797	-	543	WP_099985464.1	hypothetical protein	-
CTM68_RS04525	876069..876371	-	303	WP_008819878.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-72)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 9136.58 Da
• Isoelectric Point: 10.2817

>T88349 WP_099985459.1 NZ_CP024698:c871507-871277 [Fusobacterium pseudoperiodonticum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGVLKGIGKPEVLKNESAYSRRIDEKNRLVYRIVDGFIK

Nucleotide

• Length: 231 bp

>T88349 NZ_CP024698:c871507-871277 [Fusobacterium pseudoperiodonticum]
ATGAATAATTTGGTATGGACACATAAGGCTTGGCAAGATTACTTATATTGGCAAACTCAGGATAAAAAAACTTTGAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGTTTTAAAAGGAATAGGCAAGCCAGAAGTGTTAAAAAATGAAA
GTGCATACAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGATGGCTTTATTAAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9824.17 Da
• Isoelectric Point: 4.4453

>AT88349 WP_005892688.1 NZ_CP024698:c871754-871500 [Fusobacterium pseudoperiodonticum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Nucleotide

• Length: 255 bp

>AT88349 NZ_CP024698:c871754-871500 [Fusobacterium pseudoperiodonticum]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTTGATAACGATGAAGATAT
TATTATAACAAGAAAAAATGAGAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAGTTTTTAAAAGCTATGAGGA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAAGCAGGAAAAGGAGAAATTCATGATTTAATAGAG
GTTGATGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A806UAF3