Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3554923..3555762 | Replicon | chromosome |
| Accession | NZ_CP024679 | ||
| Organism | Citrobacter freundii strain UMH15 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2Z3WYV4 |
| Locus tag | CUC47_RS17730 | Protein ID | WP_038633771.1 |
| Coordinates | 3555385..3555762 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | CUC47_RS17725 | Protein ID | WP_121540447.1 |
| Coordinates | 3554923..3555336 (+) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CUC47_RS17680 | 3550014..3550901 | + | 888 | WP_121540445.1 | 50S ribosome-binding GTPase | - |
| CUC47_RS17685 | 3551107..3551508 | + | 402 | WP_121540446.1 | hypothetical protein | - |
| CUC47_RS17690 | 3551605..3552072 | + | 468 | WP_000727137.1 | hypothetical protein | - |
| CUC47_RS27015 | 3552263..3552513 | + | 251 | Protein_3372 | DUF905 family protein | - |
| CUC47_RS17700 | 3552629..3553447 | + | 819 | WP_001234374.1 | DUF945 domain-containing protein | - |
| CUC47_RS17705 | 3553447..3553710 | + | 264 | WP_038633754.1 | hypothetical protein | - |
| CUC47_RS17710 | 3553788..3554183 | + | 396 | WP_051594539.1 | antirestriction protein | - |
| CUC47_RS17715 | 3554236..3554721 | + | 486 | WP_038642868.1 | DNA repair protein RadC | - |
| CUC47_RS17720 | 3554733..3554954 | + | 222 | WP_038633763.1 | DUF987 domain-containing protein | - |
| CUC47_RS17725 | 3554923..3555336 | + | 414 | WP_121540447.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CUC47_RS17730 | 3555385..3555762 | + | 378 | WP_038633771.1 | TA system toxin CbtA family protein | Toxin |
| CUC47_RS17735 | 3555759..3556250 | + | 492 | WP_038633774.1 | hypothetical protein | - |
| CUC47_RS17740 | 3556280..3556474 | + | 195 | WP_038633777.1 | DUF957 domain-containing protein | - |
| CUC47_RS17745 | 3556555..3557403 | + | 849 | WP_121540448.1 | DUF4942 domain-containing protein | - |
| CUC47_RS17750 | 3557898..3558674 | - | 777 | Protein_3383 | IS5 family transposase | - |
| CUC47_RS17755 | 3559089..3559946 | + | 858 | WP_044713779.1 | hypothetical protein | - |
| CUC47_RS17760 | 3560147..3560626 | - | 480 | WP_044713777.1 | Hcp family type VI secretion system effector | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14050.89 Da Isoelectric Point: 6.8604
>T88313 WP_038633771.1 NZ_CP024679:3555385-3555762 [Citrobacter freundii]
MQTQPVSPAREASPRLSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRTVTDITTGKYSKMTR
MQTQPVSPAREASPRLSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRTVTDITTGKYSKMTR
Download Length: 378 bp
>T88313 NZ_CP024679:3555385-3555762 [Citrobacter freundii]
ATGCAAACACAACCCGTATCCCCGGCACGGGAGGCTTCTCCACGTCTGTCACCCGTGGAGATTTGGCAGCGACTTCTGAG
CCACCTGCTGGATCATCACTACGGTCTGGCGCTAAACGACACGCCGTTTGGCAACGACGACGTGATTCAGGAGCACATTG
ACGCCGGTATTTCCCTGTGTGATGCCGTCAATTTTATCGTCGAAAAATACGATCTGGTACGCACTGACCGTTACGGATCC
AGCACTACAGAGCAGTCACCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGTAAGGCCTGTGGACTGATGACACGTAA
CGGCTACAGAACGGTGACAGATATCACTACAGGCAAATACAGCAAGATGACCCGATGA
ATGCAAACACAACCCGTATCCCCGGCACGGGAGGCTTCTCCACGTCTGTCACCCGTGGAGATTTGGCAGCGACTTCTGAG
CCACCTGCTGGATCATCACTACGGTCTGGCGCTAAACGACACGCCGTTTGGCAACGACGACGTGATTCAGGAGCACATTG
ACGCCGGTATTTCCCTGTGTGATGCCGTCAATTTTATCGTCGAAAAATACGATCTGGTACGCACTGACCGTTACGGATCC
AGCACTACAGAGCAGTCACCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGTAAGGCCTGTGGACTGATGACACGTAA
CGGCTACAGAACGGTGACAGATATCACTACAGGCAAATACAGCAAGATGACCCGATGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15206.38 Da Isoelectric Point: 7.7885
>AT88313 WP_121540447.1 NZ_CP024679:3554923-3555336 [Citrobacter freundii]
MSFCAASPSVNSYSRSTTLLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQA
FPVLLKQMELMLVSGELSPRHQHCVTLYAKGLTCEADSLGSHGYIYIVIYPTPSVTS
MSFCAASPSVNSYSRSTTLLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQA
FPVLLKQMELMLVSGELSPRHQHCVTLYAKGLTCEADSLGSHGYIYIVIYPTPSVTS
Download Length: 414 bp
>AT88313 NZ_CP024679:3554923-3555336 [Citrobacter freundii]
ATGTCGTTCTGCGCAGCGTCACCCTCAGTTAACTCATATTCAAGGAGCACGACCTTGTTGAATAAAACACTGCCGGCAAA
TCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTTCGGTGCACGGCTGGTACAGGAAGGCA
ACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACGCGGATTTGCGCCATCTCGACCAAGCG
TTTCCGGTACTGCTGAAGCAAATGGAACTGATGCTGGTTTCCGGCGAACTCAGTCCCCGCCATCAGCACTGCGTCACGCT
GTATGCAAAGGGACTGACCTGCGAGGCTGACTCACTCGGATCGCATGGCTATATCTATATAGTGATTTATCCGACACCAT
CAGTAACGTCATAA
ATGTCGTTCTGCGCAGCGTCACCCTCAGTTAACTCATATTCAAGGAGCACGACCTTGTTGAATAAAACACTGCCGGCAAA
TCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTTCGGTGCACGGCTGGTACAGGAAGGCA
ACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACGCGGATTTGCGCCATCTCGACCAAGCG
TTTCCGGTACTGCTGAAGCAAATGGAACTGATGCTGGTTTCCGGCGAACTCAGTCCCCGCCATCAGCACTGCGTCACGCT
GTATGCAAAGGGACTGACCTGCGAGGCTGACTCACTCGGATCGCATGGCTATATCTATATAGTGATTTATCCGACACCAT
CAGTAACGTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|