Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3554923..3555762 Replicon chromosome
Accession NZ_CP024679
Organism Citrobacter freundii strain UMH15

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2Z3WYV4
Locus tag CUC47_RS17730 Protein ID WP_038633771.1
Coordinates 3555385..3555762 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CUC47_RS17725 Protein ID WP_121540447.1
Coordinates 3554923..3555336 (+) Length 138 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC47_RS17680 3550014..3550901 + 888 WP_121540445.1 50S ribosome-binding GTPase -
CUC47_RS17685 3551107..3551508 + 402 WP_121540446.1 hypothetical protein -
CUC47_RS17690 3551605..3552072 + 468 WP_000727137.1 hypothetical protein -
CUC47_RS27015 3552263..3552513 + 251 Protein_3372 DUF905 family protein -
CUC47_RS17700 3552629..3553447 + 819 WP_001234374.1 DUF945 domain-containing protein -
CUC47_RS17705 3553447..3553710 + 264 WP_038633754.1 hypothetical protein -
CUC47_RS17710 3553788..3554183 + 396 WP_051594539.1 antirestriction protein -
CUC47_RS17715 3554236..3554721 + 486 WP_038642868.1 DNA repair protein RadC -
CUC47_RS17720 3554733..3554954 + 222 WP_038633763.1 DUF987 domain-containing protein -
CUC47_RS17725 3554923..3555336 + 414 WP_121540447.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CUC47_RS17730 3555385..3555762 + 378 WP_038633771.1 TA system toxin CbtA family protein Toxin
CUC47_RS17735 3555759..3556250 + 492 WP_038633774.1 hypothetical protein -
CUC47_RS17740 3556280..3556474 + 195 WP_038633777.1 DUF957 domain-containing protein -
CUC47_RS17745 3556555..3557403 + 849 WP_121540448.1 DUF4942 domain-containing protein -
CUC47_RS17750 3557898..3558674 - 777 Protein_3383 IS5 family transposase -
CUC47_RS17755 3559089..3559946 + 858 WP_044713779.1 hypothetical protein -
CUC47_RS17760 3560147..3560626 - 480 WP_044713777.1 Hcp family type VI secretion system effector -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(33-132)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14050.89 Da        Isoelectric Point: 6.8604

>T88313 WP_038633771.1 NZ_CP024679:3555385-3555762 [Citrobacter freundii]
MQTQPVSPAREASPRLSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRTVTDITTGKYSKMTR

Download         Length: 378 bp

>T88313 NZ_CP024679:3555385-3555762 [Citrobacter freundii]
ATGCAAACACAACCCGTATCCCCGGCACGGGAGGCTTCTCCACGTCTGTCACCCGTGGAGATTTGGCAGCGACTTCTGAG
CCACCTGCTGGATCATCACTACGGTCTGGCGCTAAACGACACGCCGTTTGGCAACGACGACGTGATTCAGGAGCACATTG
ACGCCGGTATTTCCCTGTGTGATGCCGTCAATTTTATCGTCGAAAAATACGATCTGGTACGCACTGACCGTTACGGATCC
AGCACTACAGAGCAGTCACCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGTAAGGCCTGTGGACTGATGACACGTAA
CGGCTACAGAACGGTGACAGATATCACTACAGGCAAATACAGCAAGATGACCCGATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15206.38 Da        Isoelectric Point: 7.7885

>AT88313 WP_121540447.1 NZ_CP024679:3554923-3555336 [Citrobacter freundii]
MSFCAASPSVNSYSRSTTLLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQA
FPVLLKQMELMLVSGELSPRHQHCVTLYAKGLTCEADSLGSHGYIYIVIYPTPSVTS

Download         Length: 414 bp

>AT88313 NZ_CP024679:3554923-3555336 [Citrobacter freundii]
ATGTCGTTCTGCGCAGCGTCACCCTCAGTTAACTCATATTCAAGGAGCACGACCTTGTTGAATAAAACACTGCCGGCAAA
TCATCATATTTCTGAACCGTGGTGGGGACTGAAACGTAATATCACCCCGTGCTTCGGTGCACGGCTGGTACAGGAAGGCA
ACCGGCTGCATTATCTGGCCGACCGCGCCAGCATCACCGGGACATTCACCGACGCGGATTTGCGCCATCTCGACCAAGCG
TTTCCGGTACTGCTGAAGCAAATGGAACTGATGCTGGTTTCCGGCGAACTCAGTCCCCGCCATCAGCACTGCGTCACGCT
GTATGCAAAGGGACTGACCTGCGAGGCTGACTCACTCGGATCGCATGGCTATATCTATATAGTGATTTATCCGACACCAT
CAGTAACGTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2Z3WYV4


Antitoxin

Source ID Structure

References