Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
Location | 4726471..4727137 | Replicon | chromosome |
Accession | NZ_CP024677 | ||
Organism | Citrobacter freundii strain UMH16 |
Toxin (Protein)
Gene name | tad | Uniprot ID | - |
Locus tag | CUC48_RS23465 | Protein ID | WP_086529694.1 |
Coordinates | 4726471..4726830 (+) | Length | 120 a.a. |
Antitoxin (Protein)
Gene name | ata | Uniprot ID | - |
Locus tag | CUC48_RS23470 | Protein ID | WP_049016184.1 |
Coordinates | 4726820..4727137 (+) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CUC48_RS23455 | 4723871..4725502 | + | 1632 | WP_086529696.1 | Na/Pi cotransporter family protein | - |
CUC48_RS23460 | 4725568..4726257 | - | 690 | WP_086529695.1 | dipeptidase PepE | - |
CUC48_RS23465 | 4726471..4726830 | + | 360 | WP_086529694.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
CUC48_RS23470 | 4726820..4727137 | + | 318 | WP_049016184.1 | helix-turn-helix domain-containing protein | Antitoxin |
CUC48_RS26350 | 4727277..4727438 | - | 162 | WP_003841416.1 | phage protein | - |
CUC48_RS26355 | 4727509..4727682 | - | 174 | WP_032938222.1 | hypothetical protein | - |
CUC48_RS23480 | 4727814..4728179 | + | 366 | WP_086529693.1 | hypothetical protein | - |
CUC48_RS23485 | 4728276..4728569 | + | 294 | WP_003844689.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
CUC48_RS23490 | 4728569..4728886 | + | 318 | WP_086529692.1 | CcdB family protein | - |
CUC48_RS23495 | 4728920..4729732 | - | 813 | WP_032948295.1 | shikimate 5-dehydrogenase | - |
CUC48_RS23500 | 4729734..4730957 | - | 1224 | WP_003841404.1 | L-sorbose 1-phosphate reductase | - |
CUC48_RS23505 | 4731025..4731849 | - | 825 | WP_003031641.1 | PTS system mannose/fructose/sorbose family transporter subunit IID | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 120 a.a. Molecular weight: 13422.52 Da Isoelectric Point: 10.2555
>T88297 WP_086529694.1 NZ_CP024677:4726471-4726830 [Citrobacter freundii]
MTKPLYWVGQARKDLLAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGSAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVI
MTKPLYWVGQARKDLLAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGSAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVI
Download Length: 360 bp
>T88297 NZ_CP024677:4726471-4726830 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACTTGCTTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAGCAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCAGGGGTTC
TGGAGGTCGTTGAGGATTACCACGGTAGCGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAATCCGTTTCCGGGAAGGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCATATGA
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACTTGCTTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAGCAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCAGGGGTTC
TGGAGGTCGTTGAGGATTACCACGGTAGCGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAATCCGTTTCCGGGAAGGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCATATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11474.35 Da Isoelectric Point: 8.9375
>AT88297 WP_049016184.1 NZ_CP024677:4726820-4727137 [Citrobacter freundii]
MSYEVEASSGNVYVDLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNTSGKLKVKFG
MSYEVEASSGNVYVDLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNTSGKLKVKFG
Download Length: 318 bp
>AT88297 NZ_CP024677:4726820-4727137 [Citrobacter freundii]
ATGTCATATGAAGTGGAAGCCAGTAGCGGTAATGTTTACGTCGATTTAGGTGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAATTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCCGCGCAGCTACTGGGAA
TGACGCAGCCTAAACTTTCCAACCTGTTACGCGGTCAGTTTCGCGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGACTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAAGGCAATACGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA
ATGTCATATGAAGTGGAAGCCAGTAGCGGTAATGTTTACGTCGATTTAGGTGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAATTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCCGCGCAGCTACTGGGAA
TGACGCAGCCTAAACTTTCCAACCTGTTACGCGGTCAGTTTCGCGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGACTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAAGGCAATACGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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