Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4726471..4727137 Replicon chromosome
Accession NZ_CP024677
Organism Citrobacter freundii strain UMH16

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag CUC48_RS23465 Protein ID WP_086529694.1
Coordinates 4726471..4726830 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag CUC48_RS23470 Protein ID WP_049016184.1
Coordinates 4726820..4727137 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC48_RS23455 4723871..4725502 + 1632 WP_086529696.1 Na/Pi cotransporter family protein -
CUC48_RS23460 4725568..4726257 - 690 WP_086529695.1 dipeptidase PepE -
CUC48_RS23465 4726471..4726830 + 360 WP_086529694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUC48_RS23470 4726820..4727137 + 318 WP_049016184.1 helix-turn-helix domain-containing protein Antitoxin
CUC48_RS26350 4727277..4727438 - 162 WP_003841416.1 phage protein -
CUC48_RS26355 4727509..4727682 - 174 WP_032938222.1 hypothetical protein -
CUC48_RS23480 4727814..4728179 + 366 WP_086529693.1 hypothetical protein -
CUC48_RS23485 4728276..4728569 + 294 WP_003844689.1 type II toxin-antitoxin system CcdA family antitoxin -
CUC48_RS23490 4728569..4728886 + 318 WP_086529692.1 CcdB family protein -
CUC48_RS23495 4728920..4729732 - 813 WP_032948295.1 shikimate 5-dehydrogenase -
CUC48_RS23500 4729734..4730957 - 1224 WP_003841404.1 L-sorbose 1-phosphate reductase -
CUC48_RS23505 4731025..4731849 - 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13422.52 Da        Isoelectric Point: 10.2555

>T88297 WP_086529694.1 NZ_CP024677:4726471-4726830 [Citrobacter freundii]
MTKPLYWVGQARKDLLAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGSAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVI

Download         Length: 360 bp

>T88297 NZ_CP024677:4726471-4726830 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACTTGCTTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAGCAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCAGGGGTTC
TGGAGGTCGTTGAGGATTACCACGGTAGCGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAATCCGTTTCCGGGAAGGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCATATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11474.35 Da        Isoelectric Point: 8.9375

>AT88297 WP_049016184.1 NZ_CP024677:4726820-4727137 [Citrobacter freundii]
MSYEVEASSGNVYVDLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNTSGKLKVKFG

Download         Length: 318 bp

>AT88297 NZ_CP024677:4726820-4727137 [Citrobacter freundii]
ATGTCATATGAAGTGGAAGCCAGTAGCGGTAATGTTTACGTCGATTTAGGTGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAATTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCCGCGCAGCTACTGGGAA
TGACGCAGCCTAAACTTTCCAACCTGTTACGCGGTCAGTTTCGCGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGACTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAAGGCAATACGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References