Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4477677..4478193 Replicon chromosome
Accession NZ_CP024676
Organism Citrobacter pasteurii strain UMH17

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag CUC49_RS21855 Protein ID WP_003839578.1
Coordinates 4477909..4478193 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag CUC49_RS21850 Protein ID WP_003839576.1
Coordinates 4477677..4477919 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC49_RS21830 4472692..4473825 + 1134 WP_121585391.1 amidohydrolase/deacetylase family metallohydrolase -
CUC49_RS21835 4473809..4474927 + 1119 WP_061067122.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CUC49_RS21840 4474924..4475664 + 741 WP_121585392.1 KDGP aldolase family protein -
CUC49_RS21845 4475686..4477599 + 1914 WP_121585393.1 BglG family transcription antiterminator -
CUC49_RS21850 4477677..4477919 + 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CUC49_RS21855 4477909..4478193 + 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUC49_RS21860 4478197..4478661 - 465 WP_003839580.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CUC49_RS21865 4478846..4480984 - 2139 WP_003844922.1 anaerobic ribonucleoside-triphosphate reductase -
CUC49_RS21870 4481393..4483045 - 1653 WP_121585394.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T88278 WP_003839578.1 NZ_CP024676:4477909-4478193 [Citrobacter pasteurii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

>T88278 NZ_CP024676:4477909-4478193 [Citrobacter pasteurii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT88278 WP_003839576.1 NZ_CP024676:4477677-4477919 [Citrobacter pasteurii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT88278 NZ_CP024676:4477677-4477919 [Citrobacter pasteurii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References